Palladium-catalyzed enantioselective β-hydride elimination for the construction of remote stereocenters.

Shaozi Sun, Shengnan Sun, Weiwei Zi

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In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Asymmetric synthesis of Heteroatom-bridged [3.2.1]Octane scaffolds via enantioselective β-H elimination reaction.Nature communications · 2026
Article

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Shaozi SunState Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300071, China.

Shengnan SunState Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300071, China.

Weiwei ZiState Key Laboratory and Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300071, China. zi@nankai.edu.cn.ORCID http://orcid.org/0000-0002-7842-0174

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22071118; 22271162

6 · The paper itself

Abstract

The β-H elimination is a crucial elementary step in transition-metal catalysis, but controlling the stereochemistry of this process has been underdeveloped. The limited works reported so far have only focused on creating axial chirality in allenes, and no report has been able to build central chirality using asymmetric β-H elimination. In this study, we report a Trost ligand-enabled enantioselective desymmetric β-H elimination reaction from π-allyl-Pd. This transformation provides rapid access to cyclohexenes bearing a C4-remoted stereocenter, and total synthesis of (-)-oleuropeic acid and (-)-7-hydroxyterpineol is demonstrated. Computational studies have shown that the β-H elimination is the rate-determining step, and the non-covalent interactions between the amide moiety of the Trost ligand and the benzene and cyclohexane moieties of the substrate play a key role in stereocontrol during the β-H elimination.

Identifiers

PMID40044712

DOI10.1038/s41467-025-57437-x

PMCPMC11882921

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Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.