Evidence map›Paper›PMID 40044816›Full record

ArticleNature biomedical engineering2025

A positron emission tomography tracer for the imaging of oxidative stress in the central nervous system.

Justin H Wilde, Yu-Yo Sun, Spenser R Simpson, Ethan R Hill, Zhongxiao Fu, Emily J Bian, Melissa M Kinkaid, Paulina Villanueva, Aden F Weybright, William R Terrell and 7 more

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Next-generation molecular imaging of cardiac fibrosis.The international journal of cardiovascular imaging · 2026
    Review
  4. In Vivo Microplastic Detection With Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Justin H Wilde *Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0001-6076-5484
Yu-Yo Sun *Institute of Biopharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.
Spenser R SimpsonDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Ethan R HillDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0009-0004-3816-1771
Zhongxiao FuDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-8850-6991
Emily J BianDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Melissa M KinkaidDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Paulina VillanuevaDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Aden F WeybrightDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
William R TerrellDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Zoraiz QureshiDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Shashika S PereraDepartment of Radiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Heather S SheppardDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.
James R StoneDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Bijoy K KunduDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Chia-Yi KuanDepartment of Neuroscience, University of Virginia, Charlottesville, VA, USA.
Kiel D NeumannDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA. kiel.neumann@stjude.org.ORCID http://orcid.org/0000-0001-9093-3522

Funding

CMRO2 and Uncoupling of Oxidative-Phosphorylation in Experimental HIER01NS125677 · NINDS · UNIVERSITY OF VIRGINIA · PI Song Hu, Chia-Yi Kuan · 2022 to 2026
$2.8M
Treating neurotoxicity and cognitive deficits due to hyperphosphorylated tau.R01NS135693 · NINDS · UNIVERSITY OF VIRGINIA · PI Chia-Yi Kuan, Min-Hao Kuo · 2023 to 2026
$2.4M
Neutrophils and Monocytes in Pediatric Ischemic StrokeR01NS125788 · NINDS · UNIVERSITY OF VIRGINIA · PI Chia-Yi Kuan · 2022 to 2026
$2.1M
Novel imaging agents of oxidative stress in the pathophysiology of the central nervous systemR01EB028338 · NIBIB · UNIVERSITY OF VIRGINIA · PI NEUMANN, KIEL · 2020 to 2020
$2.1M
[18F]fluoromannitol: A novel imaging agent to delineate osteomyelitis in sickle cell diseaseR01AI192221 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Amanda Marie Green, Kiel Neumann · 2025 to 2026
$1.8M
Monocyte-Derived Microglia in Development and after Neonatal Brain InjuryR21HD109025 · NICHD · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2023 to 2024
$444k
Perivascular Fibroblast-Endothelium Interactions in Hypertension and Cerebral IschemiaR21NS127392 · NINDS · UNIVERSITY OF VIRGINIA · PI KUAN, CHIA-YI · 2022 to 2023
$444k
NIAID NIH HHS R01 AI192221NIBIB NIH HHS R01 EB028338NICHD NIH HHS R21 HD109025NINDS NIH HHS R01 NS125677NINDS NIH HHS R01 NS125788NINDS NIH HHS R01 NS135693NINDS NIH HHS R21 NS127392U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS125677U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01NS125788U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21HD109025U.S. Department of Health & Human Services | National Institutes of Health (NIH) R21NS127392U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) R01EB028338
6 · The paper itself

Abstract

Reactive oxygen and nitrogen species (RONS) contribute to the pathogenesis of neurodegeneration, but the inability to detect RONS in vivo in the central nervous system has confounded the interpretation of results of clinical trials of antioxidants. Here we report the synthesis and characterization of a positron emission tomography (PET) probe, [

Indexed as

Central Nervous SystemOxidative StressPositron-Emission TomographyAnimalsBlood-Brain BarrierBrainEdaravoneFluorine RadioisotopesHumansMaleMiceRadiopharmaceuticalsReactive Nitrogen SpeciesReactive Oxygen SpeciesStrokeEdaravoneFluorine RadioisotopesRadiopharmaceuticalsReactive Nitrogen SpeciesReactive Oxygen Species

Identifiers

PMID40044816
PMCPMC12092265

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.