ArticleNature2025
A cryptic pocket in CB1 drives peripheral and functional selectivity.
Abstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- The Endocannabinoid System in Endometriosis-Associated Pain: Mechanisms, Molecular Targets, and Therapeutic Implications.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Rational Design of GNeuroscience bulletin · 2026Article
- Lipid Activation of a Thalamic GPCR Extends Working Memory Time-scales.bioRxiv : the preprint server for biology · 2026Article
- Steric control of signaling bias in the immunometabolic receptor GPR84.Nature communications · 2026Article
- Interspecies differences in the expression of cannabinoid receptors at the tissue and cellular levels.Neural regeneration research · 2026Article
- Library Docking for Cannabinoid-2 Receptor Ligands.Journal of medicinal chemistry · 2026Article
- Discovery of a peripherally restricted αCell reports. Medicine · 2026Article
- Cryptic pockets in proteins: Harnessing conformational dynamics for rational drug design.Acta pharmaceutica Sinica. B · 2026Article
- CryptoBank: A resource for the identification and prediction of cryptic sites in proteins.Science advances · 2026Article
- Library docking for Cannabinoid-2 Receptor ligands.bioRxiv : the preprint server for biology · 2026Article
- Decrypting cryptic pockets with physics-based simulations and artificial intelligence.Current opinion in structural biology · 2026Review
- Machine learning for drug-target interaction prediction: A comprehensive review of models, challenges, and computational strategies.Computational and structural biotechnology journal · 2026Review
- Cannabinoid efficacy for pain: dose, chronicity and route.Frontiers in neuroscience · 2026Review
- Computational modelling reveals novel insights into GnRH receptor activation and binding dynamics.Scientific reports · 2025Article
- Indazole partial agonists targeting peripheral cannabinoid receptors.Bioorganic & medicinal chemistry · 2025Article
- Enhanced Sampling and Tailored Collective Variables Yield Reproducible Free Energy Landscapes of Beta-1 Adrenergic Receptor Activation.Journal of chemical theory and computation · 2025Article
- Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.Cell · 2025Article
- Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice.The journal of headache and pain · 2025Article
- Recent computational advances in the identification of cryptic binding sites for drug discovery.Bioinformatics advances · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors.
Vipin Ashok Rangari *Center for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9721-6195
Evan S O'Brien *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2260-7722
Alexander S Powers *Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Richard A Slivicki *Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3191-7749
Zachariah Bertels *Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Kevin AppourchauxCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9853-3347
Deniz AydinDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2758-2480
Nokomis Ramos-GonzalezCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9398-8956
Juliet MwirigiDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-5220-8239
Li LinDepartment of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA.
Elizaveta MangutovCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Briana L SobecksDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Yaseen Awad-AgbariaCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Manoj B UphadeCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Jhoan AguilarCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Teja Nikhil PeddadaDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Yuki ShiimuraDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Xi-Ping HuangDepartment of Pharmacology School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-2585-653X
Jakayla Folarin-HinesDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Maria PayneDepartment of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Anirudh KalathilCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Balazs R VargaCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.
Brian K KobilkaDepartment of Computer Science, Stanford University, Stanford, CA, USA.ORCID 0000-0001-5958-3990
Amynah A PradhanCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-9691-2976
Michael D CameronDepartment of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, USA.ORCID 0000-0003-3154-4775
Kaavya Krishna KumarDepartment of Computer Science, Stanford University, Stanford, CA, USA. kaavyak@stanford.edu.ORCID 0000-0003-2283-4033
Ron O DrorDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu.ORCID 0000-0002-6418-2793
Robert W GereauCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA. gereaur@wustl.edu.ORCID 0000-0002-5428-4251
Susruta MajumdarCenter for Clinical Pharmacology, University of Health Sciences and Pharmacy and Washington University School of Medicine, St. Louis, MO, USA. susrutam@email.wustl.edu.ORCID 0000-0002-2931-3823
Funding
Synthesis of peripherally active CB1 agonists as analgesicsR34NS126036 · NINDS · WASHINGTON UNIVERSITY · PI DROR, RON, GEREAU, ROBERT W · 2021 to 2021
$1.6MFunctional and molecular characterization of the central amygdala in the context of oxycodone withdrawalK99DA056691 · NIDA · WASHINGTON UNIVERSITY · PI SLIVICKI, RICHARD · 2024 to 2025
$332kEvaluation of peripheral cannabinoid receptors as a target for pain managementF32DA051160 · NIDA · WASHINGTON UNIVERSITY · PI SLIVICKI, RICHARD · 2020 to 2022
$187kNIDA NIH HHS F32 DA051160NIDA NIH HHS K99 DA056691NINDS NIH HHS R34 NS126036
Abstract
The current opioid overdose epidemic highlights the urgent need to develop safer and more effective treatments for chronic pain
Indexed as
Receptor, Cannabinoid, CB1AnalgesicsAnimalsArrestinArrestinsBinding SitesDisease Models, AnimalDrug DesignDrug ToleranceFemaleHumansLigandsMaleMiceMice, Inbred C57BLMolecular Dynamics SimulationAnalgesicsArrestinArrestinsLigandsReceptor, Cannabinoid, CB1
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.