Evidence map›Paper›PMID 40045458›Full record

ReviewClinical and translational medicine2025

Ferroptosis of T cell in inflammation and tumour immunity.

Xueli Xia, Haisheng Wu, Yuxuan Chen, Huiyong Peng, Shengjun Wang

Abstract readReview
In one paragraph

Review in Clinical and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Iron Dysregulation and Vascular Diseases: A Contemporary Review.Journal of the American Heart Association · 2026
    Review
  5. Review
  6. Ferroptosis-induced immune modulation: a new frontier in glioblastoma therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  7. The crosstalk between iron metabolism and immune tolerance in autoimmunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Recent progress in understanding ferroptosis mechanisms in infectious diseases.Frontiers in cellular and infection microbiology · 2026
    Review
  13. Review
  14. Review
  15. Review
  16. Ferroptosis of T cell in inflammation and tumour immunity.Clinical and translational medicine · 2025
    Review
  17. Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xueli XiaDepartment of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Haisheng WuDepartment of Immunology, Jiangsu University School of Medicine, Zhenjiang, China.
Yuxuan ChenDepartment of Immunology, Jiangsu University School of Medicine, Zhenjiang, China.
Huiyong PengDepartment of Laboratory Medicine, Affiliated People's Hospital, Jiangsu University, Zhenjiang, China.
Shengjun WangDepartment of Laboratory Medicine, Jiangsu Province Engineering Research Center for Precise Diagnosis and Treatment of Inflammatory Diseases, Affiliated Hospital of Jiangsu University, Zhenjiang, China.ORCID 0000-0001-6584-1183

Funding

Gynecology Project of Zhenjiang Traditional Chinese Medicine SS2021006Jiangsu Provincial Medical Key Discipline Cultivation Unit JSDW202241Key Research, Development and Transformation Program of Qinghai Province 2024-SF-124
6 · The paper itself

Abstract

Ferroptosis is an innovative concept defined as a distinct programmed cell death mode regulated by iron-dependent lipid peroxidation accumulation. This process is governed by numerous energy metabolites such as fatty acids, amino acids and glucose, as well as iron homeostasis. In recent years, increasing studies have been devoted to the crucial effects of ferroptosis in immune cells during the pathogenesis of diseases such as infections, tumours and autoimmune disorders. This review summarises the latest advancements in T-cell ferroptosis, addresses the key components and mechanism of ferroptosis in T cells during inflammatory conditions and tumour progression, and highlights the potential target for treating related diseases. KEY POINTS: Ferroptosis-related mechanisms significantly affect the biology of CD4

Indexed as

FerroptosisInflammationNeoplasmsT-LymphocytesAnimalsHumansTumor MicroenvironmentCD4+ T cellCD8+ T cellferroptosisinflammationtumour

Identifiers

PMID40045458
PMCPMC11882479

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.