Evidence map›Paper›PMID 40045464›Full record

ArticleGut microbes2025

Prediabetes and type 2 diabetes but not obesity are associated with alterations in bile acid related gut microbe-microbe and gut microbe-host community metabolism.

Kristina Schlicht, Lea Pape, Nathalie Rohmann, Carina Knappe, Johannes Epe, Corinna Geisler, Daniela Pohlschneider, Susanne Brodesser, Lucy Kruse, Maria-Elisabeth Rohlfing and 17 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Formulation-dependent kinetics ofMicrobiology spectrum · 2026
    Article
  5. Article
  6. Mechanistic Insights intoMetabolites · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Metabolic modeling of host-microbe interactions.Computational and structural biotechnology journal · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Kristina SchlichtInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID 0000-0003-0281-5142
Lea PapeInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Nathalie RohmannInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Carina KnappeInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Johannes EpeInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Corinna GeislerInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID 0000-0002-2383-3596
Daniela PohlschneiderInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Susanne BrodesserFaculty of Medicine and University Hospital of Cologne, Cluster of Excellence Cellular Stress Responses in Aging-associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lucy KruseInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Maria-Elisabeth RohlfingInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Katharina HartmannInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Kathrin TürkInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Jens MarquardtDepartment of Internal Medicine 1, University Medical Center Schleswig-Holstein, Lübeck, Germany.
Jan BeckmannDepartment of General and Abdominal Surgery, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
Witigo von SchönfelsDepartment of General and Abdominal Surgery, University Medical Center Schleswig-Holstein (UKSH), Kiel, Germany.
Alexia BeckmannDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Perdita Wietzke-BraunDivision of Endocrinology, Diabetes and Clinical Nutrition, Department of Internal Medicine I, University Medical Center Schleswig-Holstein, Kiel, Germany.
Dominik M SchulteInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Tim HollsteinInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.
Tobias DemetrowitschDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
Julia Jensen-KrollDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
Fynn BrixDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
Stefan SchreiberInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.ORCID 0000-0003-2254-7771
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, Kiel, Germany.
Karin SchwarzDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
Silvio WaschinaDivision of Food Technology, Institute of Human Nutrition and Food Science, Kiel University, Kiel, Germany.
Matthias LaudesInstitute of Diabetes and Clinical Metabolic Research, University Medical Center Schleswig-Holstein, Kiel, Germany.ORCID 0000-0002-7846-955X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interplay between bile acids (BAs) and metabolic diseases has gained importance in recent years, with a variety of studies investigating their relationship with diverging results. Therefore, in the present study we performed a detailed analysis of BA metabolism in 492 subjects with different metabolic phenotypes. Besides microbiomics and metabolomics this investigation included

Indexed as

BacteriaBile Acids and SaltsDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeObesityPrediabetic StateAdultAgedFemaleHost Microbial InteractionsHumansMaleMetabolomicsMiddle AgedTaurineBile Acids and SaltsTaurineBile acidsgut community metabolismgut microbiometype 2 diabetes

Identifiers

PMID40045464
PMCPMC11901388

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.