Evidence map›Paper›PMID 40045935›Full record

ArticleFrontiers in dental medicine2025

Characterization of clustered bacteriocin-type signal domain protein genes in

Tomoyuki Nukaga, Eitoyo Kokubu, Kazuko Okamoto-Shibayama, Yuichiro Kikuchi, Masahiro Furusawa, Takashi Muramatsu, Kazuyuki Ishihara

Abstract read
In one paragraph

Article in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tomoyuki NukagaDepartment of Endodontics, Tokyo Dental College, Tokyo, Japan.
Eitoyo KokubuDepartment of Microbiology, Tokyo Dental College, Tokyo, Japan.
Kazuko Okamoto-ShibayamaDepartment of Microbiology, Tokyo Dental College, Tokyo, Japan.
Yuichiro KikuchiDepartment of Microbiology, Tokyo Dental College, Tokyo, Japan.
Masahiro FurusawaDepartment of Endodontics, Tokyo Dental College, Tokyo, Japan.
Takashi MuramatsuDepartment of Operative Dentistry, Cariology, and Pulp Biology, Tokyo Dental College, Tokyo, Japan.
Kazuyuki IshiharaDepartment of Microbiology, Tokyo Dental College, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Periodontitis is caused by the dysbiosis of subgingival plaque, and Methods: Gene clusters surrounding bacteriocin-type signal domain protein genes were compared in silico. The expression of proteins and transporters was evaluated using real-time quantitative reverse transcription PCR (qRT-PCR). Bacteriocin-type signal domain proteins were detected using immunoblot analysis. The expression of bacteriocin-like proteins was investigated by co-culturing with Results: The DNA sequences of the bacteriocin-type signal domain protein genes and upstream lipoprotein genes were highly conserved. Expression of the bacteriocin-type signal domain protein and Conclusion: Three tandem lipoprotein-bacteriocin-type signal domain protein genes may have originated from duplication. Bacteriocin-type signal domain proteins are expressed under unstimulated conditions and are secreted by

Indexed as

bacteriocinbacteriocin ABC transporterclustered lipoproteinperiodontitisTreponema denticola

Identifiers

PMID40045935
PMCPMC11879956

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.