Evidence map›Paper›PMID 40046174›Full record

ArticleJournal of asthma and allergy2025

Glucagon-Like Peptide 1 Receptor (

Yeon Ji Kim, Victoria M Ihrie, Pixu Shi, Mark D Ihrie, Jack T Womble, Anna Hill Meares, Joshua A Granek, Claudia K Gunsch, Jennifer L Ingram

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yeon Ji Kim *Department of Civil and Environmental Engineering, Pratt School of Engineering, DukeUniversity, Durham, NC, USA.ORCID 0000-0002-1118-5026
Victoria M Ihrie *Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Pixu ShiBiostatistics and Bioinformatics, Division of Integrative Genomics, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Mark D IhrieDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Jack T WombleDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0001-8194-5038
Anna Hill MearesDepartment of Civil and Environmental Engineering, Pratt School of Engineering, DukeUniversity, Durham, NC, USA.
Joshua A GranekBiostatistics and Bioinformatics, Division of Integrative Genomics, Department of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0003-3908-5016
Claudia K GunschDepartment of Civil and Environmental Engineering, Pratt School of Engineering, DukeUniversity, Durham, NC, USA.
Jennifer L IngramDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.ORCID 0000-0002-5269-8864

Funding

Mechanisms that Direct Airway Remodeling in Obese AsthmaR01HL130234 · NHLBI · DUKE UNIVERSITY · PI INGRAM, JENNIFER L. · 2017 to 2020
$2.1M
NHLBI NIH HHS R01 HL130234
6 · The paper itself

Abstract

Purpose: High body mass index (≥30 kg/m Methods: Male and female Results: HFD led to metabolic imbalance characterized by lower GLP-1 and higher leptin levels, increased glucose intolerance, and alterations in gut microbiome composition. Prevalence of bacteria associated with short chain fatty acid (SCFA) production, namely Conclusion: Herein, GLP-1R deficiency had surprisingly little effect on host gut and lung microbiomes and health, despite recent studies suggesting that GLP-1 receptor agonists are protective against lung inflammation.

Indexed as

allergic airways diseasegut-lung microbiome axisshort-chain fatty acidsvertical sleeve gastrectomy

Identifiers

PMID40046174
PMCPMC11880686

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.