Evidence map›Paper›PMID 40046176›Full record

ArticleBrain, behavior, & immunity - health2025

Understanding, predicting, and treating depression in pregnancy to improve mothers' and offspring's mental health outcomes: The HappyMums study.

A Biaggi, V Zonca, C Anacker, V Begni, F Benedetti, A Bramante, A Braniecka, V Brenna, M Bulgheroni, C Buss and 31 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

A BiaggiDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
V ZoncaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
C AnackerDivision of Systems Neuroscience, Research Foundation for Mental Hygiene, Inc.(RFMH) / New York State Psychiatric Institute (NYSPI), Department of Psychiatry, Columbia University Irving Medical Center (CUIMC), New York, NY, 10032, USA.
V BegniBiological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, 25125, Brescia, Italy.
F BenedettiIRCCS San Raffaele Scientific Institute, Milan, Italy.
A BramantePolicentro Salute Ambulatory, Italian Marcé Society, Milan, Italy.
A BranieckaInstitute of Psychology, SWPS University, Chodakowska 19/31, 03-815, Warsaw, Poland.
V BrennaDepartment of Mental Health and Addiction Services, Niguarda Hospital, Italian Marcé Society, Milan, Italy.
M BulgheroniAb.Acus S.r.l, Italy.
C BussCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117, Berlin, Germany.
L CavaliereDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
C A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands.
A C CouchDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
D de BarraTommy's, United Kingdom.
H El MarrounDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center - Sophia Children's Hospital, Rotterdam, the Netherlands.
S EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Medical Psychology, 10117, Berlin, Germany.
R Grassi-OliveiraTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, A701-129, 8200, Aarhus, Denmark.
M JackowskaFaculty of Psychology, SWPS University, Polna 16/20, 81-745, Sopot, Poland.
A KorosiSwammerdam Institute of Life Sciences, Center for Neuroscience, Brain Plasticity Group, University of Amsterdam, Amsterdam, the Netherlands.
P J C KwantExperimental Zoology Group, Department of Animal Sciences, Wageningen University, Wageningen, the Netherlands.
J LahtiDepartment of Psychology, University of Helsinki, Helsinki, Finland.
K LekadirUniversitat de Barcelona, Artificial Intelligence in Medicine Lab (BCN-AIM), Department of Mathematics and Computer Science, Barcelona, Spain.
I MansuyLaboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zurich and Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
F ManuellaLaboratory of Neuroepigenetics, Brain Research Institute, Medical Faculty of the University of Zurich and Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
M MarizzoniBiological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, 25125, Brescia, Italy.
U MeyerZurich Neuroscience Center, ETH and University of Zurich, Zurich, Switzerland.
C MonkColumbia University Vagelos College of Physicians and Surgeons, USA.
S Nakić RadošUniversity Department of Psychology, Catholic University of Croatia, Zagreb, Croatia.
C M ParianteInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
B J A PolluxExperimental Zoology Group, Department of Animal Sciences, Wageningen University, Wageningen, the Netherlands.
K PriestleyInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
K RäikkönenDepartment of Psychology, University of Helsinki, Helsinki, Finland.
J RichettoZurich Neuroscience Center, ETH and University of Zurich, Zurich, Switzerland.
M A RivaDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
L M RothmannTranslational Neuropsychiatry Unit, Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 11, A701-129, 8200, Aarhus, Denmark.
V SimonettiAb.Acus S.r.l, Italy.
B VaiIRCCS San Raffaele Scientific Institute, Milan, Italy.
A C VernonDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
M ŽutićUniversity Department of Psychology, Catholic University of Croatia, Zagreb, Croatia.
A CattaneoDepartment of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy.
HappyMums Consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Perinatal depression is common: on average, more than 13% of women suffer from physician-diagnosed disorder and 20% report symptoms bearing clinical relevance. Maternal depression not only significantly impacts women's quality of life but also increases the offspring's risk of negative developmental outcomes, including mental disorders, through a combination of maternal alterations in Methods: HappyMums will use data from a large collection of cohorts and registries containing biological, clinical, socio-demographic, environmental, and lifestyle data. It will pool unique human samples of maternal blood, placenta, chorionic villi and amniotic fluid, analyzing these data alongside pre-clinical samples of brain, blood and placental tissue from models of prenatal stress in mice and livebearing fish for correlative analyses. HappyMums will develop a mobile application (App) to collect multiple data types from women for early screening and monitoring of depressive symptoms. Conclusion: The findings generated by HappyMums will be clinically relevant as they will increase the knowledge on perinatal depression, with unprecedented benefits for the offspring and the society as a whole.

Indexed as

Biological mechanismsIntergenerational transmissionOffspringPerinatal depressionPregnancyRisk factors

Identifiers

PMID40046176
PMCPMC11880600

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.