Evidence map›Paper›PMID 40046436›Full record

ArticleFrontiers in neuroscience2025

Chemogenetic modulation of the rat locus coeruleus alters hippocampal noradrenaline release and modulates perforant path-evoked responses.

Sielke Caestecker, Emma Lescrauwaet, Kristl Vonck, Mathieu Sprengers, Evelien Carrette, Paul Boon, Lars Emil Larsen, Robrecht Raedt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sielke Caestecker4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Emma Lescrauwaet4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Kristl Vonck4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Mathieu Sprengers4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Evelien Carrette4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Paul Boon4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Lars Emil Larsen4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.
Robrecht Raedt4BRAIN, Department of Head and Skin, Ghent University, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The locus coeruleus (LC)-noradrenaline (NA) system plays a crucial role in modulating neuronal excitability and plasticity. In epilepsy, the LC-NA system plays an important role in regulating seizure thresholds and severity, with elevated NA release mediating the seizure-suppressing effects of vagus nerve stimulation (VNS). We investigated whether chemogenetic LC activation is able to increase hippocampal NA release and affect hippocampal electrophysiology in anesthetized rats. Methods: 22 male Sprague-Dawley rats were injected with the viral vector AAV9-hSyn-NE2m in the hippocampus to induce expression of the GRAB Results: In a significant number of rats (7/15) we found an increase in hippocampal NA release, field excitatory post synaptic potential (fEPSP) slope and population spike (PS) amplitude, indicating an increase in excitatory neurotransmission and neuronal output. 4/15 rats showed a decrease in NA release without changes in fEPSP slope or PS amplitude, and 4/15 showed no change in NA release. Discussion: These findings indicate that chemogenetic activation of the LC-NA system can modulate hippocampal evoked responses, supporting further exploration of its role in health and disease, such as in epilepsy.

Indexed as

chemogeneticsepilepsyevoked potentials (EPs)GRABNE2m biosensorhippocampus (HC)locus coeruleus (LC)noradrenaline (NA)

Identifiers

PMID40046436
PMCPMC11880610

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.