Evidence map›Paper›PMID 40046643›Full record

ArticleJAR life2025

Pre-surgical memory impairment is associated with risk of postoperative cognitive dysfunction in a large geriatric cohort.

Kiri T Granger, Claudia Spies, Sheryl Caswell, Daniel Hadzidiakos, Saya Speidel, Arjen Jc Slooter, Ilse Kant, Sophie K Piper, Simone Jt van Montfort, Jennifer H Barnett and 2 more

Erratum issued 2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JAR life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07576517 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2030Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07576543 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2031Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kiri T GrangerMonument Therapeutics Ltd., Alderley Park, Congleton Road, Macclesfield, SK10 4TG, UK.
Claudia SpiesDepartment of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Sheryl CaswellMonument Therapeutics Ltd., Alderley Park, Congleton Road, Macclesfield, SK10 4TG, UK.
Daniel HadzidiakosDepartment of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Saya SpeidelDepartment of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Arjen Jc SlooterDepartments of Psychiatry and Intensive Care Medicine and Brain Center University Medical Center Utrecht (UMC), UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Ilse KantDepartments of Psychiatry and Intensive Care Medicine and Brain Center University Medical Center Utrecht (UMC), UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Sophie K PiperInstitute of Biometry and Clinical Epidemiology, Charité - Universitätsmedizin Berlin, Germany.
Simone Jt van MontfortDepartments of Psychiatry and Intensive Care Medicine and Brain Center University Medical Center Utrecht (UMC), UMC Utrecht, Utrecht University, Utrecht, the Netherlands.
Jennifer H BarnettMonument Therapeutics Ltd., Alderley Park, Congleton Road, Macclesfield, SK10 4TG, UK.
Paula M MoranMonument Therapeutics Ltd., Alderley Park, Congleton Road, Macclesfield, SK10 4TG, UK.
Friedrich BorchersDepartment of Anesthesiology and Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some patients undergoing surgical procedures display long-term post-surgery cognitive impairment (post-operative cognitive dysfunction; POCD), which may precipitate progression to dementia. We investigated whether preoperative cognitive impairment defined using specific cognitive tests (Paired-Associates Learning and Spatial-Span from the Cambridge Neuropsychological Test Automated Battery, (CANTAB) was associated with increased risk of POCD. N = 590 patients >65years and a matched control group n=114 comprised the final sample. Patients were classified as impaired if a composite memory-score derived from two tests from the CANTAB test battery (spatial working memory and paired-associate learning) scored 1 SD below norms derived from a normative database. Risk of developing POCD 3 months post-surgery was higher [odds ratio 2.048 (95% CI 1.027 - 4.087)] for those with pre-surgical cognitive impairment compared to those with no impairment. This suggests that impairment on hippocampus-based tasks spatial-span memory and paired-associates learning is associated with increased risk for POCD in older surgical patients.

Indexed as

AgeMemory impairmentPost operative cognitive dysfunctionRisk predictors

Identifiers

PMID40046643
PMCPMC11863874

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.