Evidence map›Paper›PMID 40046676›Full record

ArticleInternational journal of cardiology. Congenital heart disease2025

Does stroke volume limit exercise capacity in TGA patients after the arterial switch operation?

Renée S Joosen, Michiel Voskuil, Wieke G de Pater, Sebastiaan W H van Wijk, Dominika Suchá, Abraham van Wijk, Heleen B van der Zwaan, Gregor J Krings, Tim Takken, Johannes M P J Breur

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Article in International journal of cardiology. Congenital heart disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Renée S JoosenDepartment of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Michiel VoskuilDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Wieke G de PaterDepartment of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Sebastiaan W H van WijkDepartment of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Dominika SucháDepartment of Radiology and Nuclear Medicine, University Medical Centre Utrecht/Wilhelmina Children's Hospital, Utrecht, the Netherlands.
Abraham van WijkDepartment of Pediatric Cardiothoracic Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.
Heleen B van der ZwaanDepartment of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Gregor J KringsDepartment of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
Tim TakkenDepartment of Medical Physiology, Child Development and Exercise Center, University Medical Center Utrecht, Utrecht, the Netherlands.
Johannes M P J BreurDepartment of Pediatric Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with transposition of the great arteries (TGA) experience reduced exercise capacity after the arterial switch operation (ASO), possibly due to limited stroke volume. This study evaluates the role of stroke volume in reduced exercise capacity in these patients. Methods: A retrospective analysis was conducted on TGA patients who underwent a transthoracic echocardiogram (TTE), cardiac magnetic resonance (CMR) and cardiopulmonary exercise test (CPET) within one year between September 2009 and February 2024 at the University Medical Center Utrecht. Excluding those with submaximal CPET results, the remaining patients were divided into <18 and ≥ 18 years old groups. Reduced exercise capacity was defined as a peak oxygen uptake (VO Results: A total of 126 patients (72 % male, mean age 19 ± 8 years) were included. Left ventricular function, RV volumes, function and strain were relatively preserved on CMR. Reduced VO Conclusion: Exercise capacity in TGA patients after ASO might be limited by an impaired ability to increase stroke volume.

Indexed as

Arterial switch operationCardiac magnetic resonance imagingExercise capacityTransposition of the great arteriesVentricular function

Identifiers

PMID40046676
PMCPMC11880735

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.