Evidence map›Paper›PMID 40046770›Full record

ArticleToxicology research2025

Toxicity assessment of imatinib mesylate and a related impurity: in vitro and in vivo approaches.

Cássia Franciele Rosa da Silva Rocha, Bruna Saraiva Hermmann, Juliana Machado Kayser, Gabriela Zimmermann Prado Rodrigues, Günther Gehlen, Fernanda Brião Menezes Boaretto, Jaqueline Nascimento Picada, Juliane Deise Fleck, Mariele Feiffer Charão, Simone Gasparin Verza

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In one paragraph

Article in Toxicology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cássia Franciele Rosa da Silva RochaBioanalysis Laboratory, Health Sciences Institute, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Bruna Saraiva HermmannMolecular Microbiology Laboratory, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Juliana Machado KayserPostgraduate Program in Environmental Quality, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Gabriela Zimmermann Prado RodriguesPostgraduate Program in Environmental Quality, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Günther GehlenPostraduate Program in Toxicology, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Fernanda Brião Menezes BoarettoProkaryotic Toxicogenetics Laboratory, ULBRA, Farroupilha Avenue, 8001 Canoas, 92425-020, Brazil.
Jaqueline Nascimento PicadaProkaryotic Toxicogenetics Laboratory, ULBRA, Farroupilha Avenue, 8001 Canoas, 92425-020, Brazil.
Juliane Deise FleckPostraduate Program in Toxicology, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.
Mariele Feiffer CharãoBioanalysis Laboratory, Health Sciences Institute, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.ORCID https://orcid.org/0000-0001-7774-7063
Simone Gasparin VerzaBioanalysis Laboratory, Health Sciences Institute, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.ORCID https://orcid.org/0000-0001-9581-7272

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imatinib mesylate (IM) is a widely used anticancer drug, mainly for treating chronic myeloid leukemia. However, pharmaceutical formulations may contain impurities, which in some cases can be more toxic than the parent compounds. This study aimed to compare the toxicity of IM and one of its impurities (IMP), N-(2-methyl-5-aminophenyl)-4-(3-pyridyl)-2-pyrimidine amine, using progressively complex models. Cytotoxicity was evaluated using 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium, neutral red uptake and sulforhodamine B colorimetric assays. Mutagenic activity was assessed using the Ames test

Indexed as

Ames testC, eleganscytotoxicityimatinib mesylateimpurityzebrafish embryos

Identifiers

PMID40046770
PMCPMC11878528

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.