The exploration of therapeutic potential of bioflavonoids in metabolic acidosis and inflammation-associated with acute kidney injury: Therapeutic potential of bioflavonoids in acute kidney injury.

Maha M Al-Bazi, Abeer A Banjabi, Fares K Khalifa, Bahiya Osrah, Hayat M Albishi, Aliaa M Sabban, Sahar A Alkhodair, Rasha H Hussein

Abstract read

PubMed Full text at PMC

In one paragraph

Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Hesperidin and Its Polylactic-ACS omega · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maha M Al-BaziDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Abeer A BanjabiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Fares K KhalifaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Bahiya OsrahDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Hayat M AlbishiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Aliaa M SabbanDepartment of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Sahar A AlkhodairDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

Rasha H HusseinDepartment of Biological sciences, College of Science, University of Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The goal of this study was to estimate and compare the prospective therapeutic impacts of different types of bioflavonoids (flavonols, flavanones, and isoflavones) on acute kidney injury (AKI) induced by glycerol in male rats. Methods: Fifty adult male albino rats (Sprague-Dawley) were separated into five groups: G1, control; G2, rats injected (i.m.) by glycerol (50%) (10 mL/kg b. w.) to induce AKI; G3, G4, and G5, rats received quercetin (QUR), hesperidin (HSP), and genistein (GEN), respectively, after 24 h of glycerol injection for 42 successive days. Results: Treatment with bioflavonoids improved the renal tissue levels of antioxidant biomarkers (superoxide dismutase, glutathione, catalase, nitric oxide, inflammatory cytokines (interleukin-6, interleukin-1 βeta, nuclear factor kappa-B, tumor necrosis factor-alpha), kidney function markers (creatinine, urea, urine albumin creatinine ratio, albumin) as compared to nephrotoxic groups. QUR extract reduced the serum level of kidney function parameters in glycerol-injected rats more significantly ( Conclusion: The study results demonstrated the therapeutic effect of bioflavonoids against AKI induced by glycerol. Different types of bioflavonoids could reduce oxidative stress, inhibit the production of inflammatory mediators and cytokines, and improve renal function.

Indexed as

Acute kidney injurybioflavonoidsgenisteinhesperidininflammationmetabolic acidosisnephrotoxicityquercetin

Identifiers

PMID40046793

PMCPMC11877053

What Socratic holds

Textmetadata

LicenceCC BY-NC-SA

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.