Evidence map›Paper›PMID 40047063›Full record

ArticleEnvironmental science & technology2025

Profiling of Environmental Mixtures Containing Metals for Their Toxicity Pathways and Mechanism of Action.

Masato Ooka, Jinghua Zhao, Li Zhang, Ruili Huang, Srilatha Sakamuru, Charlotte TeKrony, Jui-Hua Hsieh, Bradley J Collins, June K Dunnick, Darlene Dixon and 1 more

Abstract read
In one paragraph

Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Association between metal co-exposure and frailty: exploring the potential explanatory pathway of inflammation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Masato OokaDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.ORCID 0000-0002-2729-2619
Jinghua ZhaoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.
Li ZhangDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.
Ruili HuangDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.ORCID 0000-0001-8886-8311
Srilatha SakamuruDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.ORCID 0000-0002-9693-1832
Charlotte TeKronyDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.
Jui-Hua HsiehDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States.ORCID 0000-0003-1620-1571
Bradley J CollinsDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States.
June K DunnickDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States.
Darlene DixonDivision of Translational Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, Durham 27709, North Carolina, United States.ORCID 0000-0002-7001-2985
Menghang XiaDivision of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville 20850, Maryland, United States.ORCID 0000-0001-7285-8469

Funding

Pathobiology Of Uterine Leiomyomas (fibroids)ZIAES021196 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DIXON, DARLENE · 2009 to 2025
$31.7M
Combined Exposures and Mixtures Research ProgramZIAES103373 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI RIDER, CYNTHIA · 2022 to 2025
$5.6M
Chemistry Services Supporting the Division of Translational ToxicologyZICES103391 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WAIDYANATHA, SURAMYA · 2023 to 2025
$3.1M
Intramural NIH HHS ZIA ES021196Intramural NIH HHS ZIA ES103373Intramural NIH HHS ZIC ES103391
6 · The paper itself

Abstract

Superfund sites are where soil, air, and water are polluted with hazardous materials. Individuals residing and working in these areas are often exposed to metals and other hazardous materials, leading to many adverse health outcomes, including cancer. While individuals are often exposed to multiple chemicals simultaneously, the combined effect of such exposures remains largely unexplored. Here, we investigated the toxicity of metal mixtures in five categories of

Indexed as

MetalsAnimalsDNA DamageHumansInterleukin-8Oxidative StressInterleukin-8MetalsangiogenesiscytokineDNA damageheavy metalmetal compound mixtureoxidative stress

Identifiers

PMID40047063
PMCPMC13022995

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.