Observational studyHeart and vessels2025
Impact of quantitative flow ratio on outcomes after percutaneous coronary intervention for chronic total occlusion.
Observational study in Heart and vessels, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical implication of a post-percutaneous coronary intervention (PCI) quantitative flow ratio (QFR) in coronary artery disease (CAD) patients with chronic total occlusion (CTO) remains insufficiently explored. This single-center retrospective observational study analyzed 195 CTO lesions from 195 CAD patients who underwent successful PCI with drug-eluting stent implantation and were assessed for post-PCI QFR. The primary end point was target lesion revascularization (TLR) at 3 years. The receiver-operating characteristic curve was used to calculate the optimal cutoff value of post-PCI QFR for predicting 3-year TLR. Patients were stratified on the basis of the optimal cutoff value, and the predictors for 3-year TLR were assessed by multivariate Cox proportional hazard models. The ROC curve demonstrated that the cutoff value of post-PCI QFR for predicting 3-year TLR was 0.84, with a sensitivity of 61% and specificity of 66%. The cumulative incidence of TLR at 3 years was significantly higher in the low post-PCI QFR group (≤ 0.84) compared to the high post-PCI QFR group (> 0.84) (22.0% versus 8.4%, P = 0.017). In multivariate analysis, age (hazard ratio [HR], 0.94 [0.91 to 0.98]), renal failure on dialysis (HR, 3.89 [1.58 to 9.55]), ostial lesion (HR, 5.01 [1.90 to 13.23]), and post-PCI QFR ≤ 0.84 (HR, 2.49 [1.04 to 5.97]) were independent predictors for 3-year TLR. Lower post-PCI QFR was associated with increased 3-year TLR in CAD patients with CTO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.