Evidence map›Paper›PMID 40047925›Full record

ArticlePediatric nephrology (Berlin, Germany)2025

Reduced kidney function in very-low-birth-weight preterm infants at preschool age.

Chia-Huei Chen, Jui-Hsing Chang, Chyong-Hsin Hsu, Mary Hsin-Ju Ko, Chia-Ying Lin, Tzu-Hua Lin, Jeng-Daw Tsai, Hung-Yang Chang

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Article in Pediatric nephrology (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chia-Huei ChenDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Jui-Hsing ChangDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Chyong-Hsin HsuDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Mary Hsin-Ju KoDepartment of Pediatrics, Hsinchu Municipal MacKay Children Hospital, Hsinchu, Taiwan.
Chia-Ying LinDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Tzu-Hua LinDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Jeng-Daw TsaiDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan.
Hung-Yang ChangDepartment of Pediatrics, MacKay Children's Hospital, No. 92, Sec. 2, Zhongshan N. Rd., Taipei City, 10449, Taiwan. drhychang@gmail.com.ORCID http://orcid.org/0000-0003-1295-8040

Funding

Mackay Memorial Hospital MMH-109-81
6 · The paper itself

Abstract

backgroundVery-low-birth-weight (VLBW) infants have significant risk factors for adverse health outcomes. Previous studies have focused on neurological, pulmonary, and cardiovascular complications, but the long-term outcomes of other organ functions particularly kidney function warrant further investigation. This prospective study aimed to compare kidney function between VLBW preterm and term infants at 5-6 years of age.

methodsParticipants underwent comprehensive assessments of kidney function and blood pressure. Estimated glomerular filtration rates (eGFR) for serum creatinine (Cr) and cystatin C (CysC) were calculated using the CKiD-U25 equations, and comparative analyses conducted between preterm and term groups. In the preterm group, perinatal growth rates of weight and height at various stages were monitored to investigate their potential association with kidney function.

resultsA total of 61 VLBW preterm and 40 term children participated in the study. The preterm group exhibited significantly higher serum CysC levels (0.97 vs. 0.87 mg/L, p = 0.001), lower eGFR-CysC (82.3 vs. 93.0 mL/min/1.73 m

conclusionsKidney function may be diminished in VLBW preterm children at preschool age. However, no significant effects of perinatal risk factors or growth on kidney function were observed. These findings underscore the importance of ongoing long-term monitoring of kidney health in this vulnerable population.

Indexed as

Infant, PrematureInfant, Very Low Birth WeightKidneyBlood PressureChildChild, PreschoolCreatinineCystatin CFemaleGlomerular Filtration RateHumansInfant, NewbornKidney Function TestsMaleProspective StudiesRisk FactorsCreatinineCystatin CBlood pressureChildrenKidney functionPretermVery low birth weight

Identifiers

PMID40047925

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.