ArticleThe Journal of infectious diseases2025
Compromised Intestinal Barrier Resilience to Disruption in People With HIV.
Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Senescence-associated loss of intestinal α1,2-fucose disrupts a modifiable host-microbiome homeostasis axis in people with HIV.bioRxiv : the preprint server for biology · 2026Article
- Mucosal and systemic immune signatures reveal compartmentalized regulation of gut barrier integrity in virologically suppressed HIV Infection.Frontiers in immunology · 2026Article
- Abnormal characteristics of intestinal microenvironment in HIV immunological non-responders.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
People with HIV (PWH) experience chronic intestinal barrier dysfunction, which contributes to chronic inflammation and its comorbidities. The mechanisms underlying this phenomenon remain unclear. We hypothesize that living with HIV compromises the intestinal barrier's resilience to injurious agents, increasing susceptibility to leakage upon exposure to disruptors. Using intestinal organoids (colonoids and enteroids) derived from PWH and controls, we assessed the impact of alcohol and inflammatory cytokines on barrier integrity. Organoids from PWH exhibited reduced resilience to disruption compared to controls, correlating with alterations in pathways critical to epithelial integrity. These findings reveal a novel mechanism underlying intestinal dysfunction in PWH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.