Evidence map›Paper›PMID 40050004›Full record

Trial reportHeart (British Cardiac Society)2025

Epicardial adipose tissue, myocardial remodelling and adverse outcomes in asymptomatic aortic stenosis: a post hoc analysis of a randomised controlled trial.

Jolien Geers, Nipun Manral, Aryabod Razipour, Caroline Park, Guadalupe Flores Tomasino, Emily Xing, Kajetan Grodecki, Jacek Kwiecinski, Tania Pawade, Mhairi K Doris and 8 more

Registry-linked trialAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Heart (British Cardiac Society), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02132026 (SALTIRE II), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02132026 phase2completednot on this map

SALTIRE II: Bisphosphonates and RANKL Inhibition in Aortic Stenosis

TypeinterventionalSponsorUniversity of EdinburghRan2014 to 2019Enrolled152ConditionsCalcific Aortic StenosisArmsDenosumab, Alendronic Acid, Denosumab Placebo, Alendronic Acid Placebo
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Observational
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jolien GeersBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0003-1109-5191
Nipun ManralBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Aryabod RazipourBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Caroline ParkBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Guadalupe Flores TomasinoBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Emily XingBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kajetan GrodeckiBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jacek KwiecinskiDepartment of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland.
Tania PawadeBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Mhairi K DorisBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Rong BingBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Audrey C WhiteBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
Steven DroogmansDepartment of Cardiology, Centrum voor Hart- en Vaatziekten (CHVZ), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussel, Belgium.
Bernard CosynsDepartment of Cardiology, Centrum voor Hart- en Vaatziekten (CHVZ), Universitair Ziekenhuis Brussel (UZ Brussel), Vrije Universiteit Brussel (VUB), Brussel, Belgium.
Piotr J SlomkaDivision of Artificial Intelligence in Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID 0000-0002-6110-938X
David E NewbyBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7971-4628
Marc R DweckBritish Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.ORCID 0009-0005-1991-0017
Damini DeyBiomedical Imaging Research Institute, department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA damini.dey@cshs.org.ORCID 0000-0003-2236-6970

Funding

Integrated prediction of cardiovascular events by automated coronary plaque and pericoronary adipose tissue quantification from CT AngiographyR01HL148787 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI · 2020 to 2023
$3.0M
AI-enabled characterization of fibrocalcific aortic valve disease and inflammation from CT Angiography: Patient-specific outcome predictionR01HL175875 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI Damini Dey · 2024 to 2026
$2.4M
Effect of Intensive Medical Treatment on Quantified Coronary Artery Plaque Components with Serial Coronary CTA in Women with Non-Obstructive CADR01HL151266 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI DEY, DAMINI, TAMARAPPOO, BALAJI K. · 2020 to 2023
$1.6M
British Heart Foundation CH/09/002, RG/F/22/110093, RE/24/130012British Heart Foundation FS/SCRF/21/32010NHLBI NIH HHS R01 HL148787NHLBI NIH HHS R01 HL151266NHLBI NIH HHS R01 HL175875
6 · The paper itself

Abstract

backgroundEpicardial adipose tissue represents a metabolically active visceral fat depot that is in direct contact with the left ventricular myocardium. While it is associated with coronary artery disease, little is known regarding its role in aortic stenosis. We sought to investigate the association of epicardial adipose tissue with aortic stenosis severity and progression, myocardial remodelling and function, and mortality in asymptomatic patients with aortic stenosis.

methodsIn a post hoc analysis of 124 patients with asymptomatic mild-to-severe aortic stenosis participating in a prospective clinical trial, baseline epicardial adipose tissue was quantified on CT angiography using fully automated deep learning-enabled software. Aortic stenosis disease severity was assessed at baseline and 1 year. The primary endpoint was all-cause mortality.

resultsNeither epicardial adipose tissue volume nor attenuation correlated with aortic stenosis severity or subsequent disease progression as assessed by echocardiography or CT (p>0.05 for all). Epicardial adipose tissue volume correlated with plasma cardiac troponin concentration (r=0.23, p=0.009), left ventricular mass (r=0.46, p<0.001), ejection fraction (r=-0.28, p=0.002), global longitudinal strain (r=0.28, p=0.017), and left atrial volume (r=0.39, p<0.001). During the median follow-up of 48 (IQR 26-73) months, a total of 23 (18%) patients died. In multivariable analysis, both epicardial adipose tissue volume (HR 1.82, 95% CI 1.10 to 3.03; p=0.021) and plasma cardiac troponin concentration (HR 1.47, 95% CI 1.13 to 1.90; p=0.004) were associated with all-cause mortality, after adjustment for age, body mass index and left ventricular ejection fraction. Patients with epicardial adipose tissue volume >90 mm

conclusionsEpicardial adipose tissue volume does not associate with aortic stenosis severity or its progression but does correlate with blood and imaging biomarkers of impaired myocardial health. The latter may explain the association of epicardial adipose tissue volume with an increased risk of all-cause mortality in patients with asymptomatic aortic stenosis. CLINICALTRIALS: gov (NCT02132026).

Indexed as

Adipose TissueAortic Valve StenosisPericardiumVentricular RemodelingAgedAsymptomatic DiseasesComputed Tomography AngiographyDisease ProgressionEchocardiographyEpicardial Adipose TissueFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexAortic stenosisComputed Tomography AngiographyRisk Assessment

Identifiers

PMID40050004
PMCPMC12202173

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.