Evidence map›Paper›PMID 40050256›Full record

ArticleGut microbes2025

Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease.

I-Wen Wu, Yu-Chieh Liao, Tsung-Hsien Tsai, Chieh-Hua Lin, Zhao-Qing Shen, Yun-Hsuan Chan, Chih-Wei Tu, Yi-Ju Chou, Chi-Jen Lo, Chi-Hsiao Yeh and 9 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  9. Aging-related CD8PeerJ · 2026
    Article
  10. Protective Effects of Orally AdministeredInternational journal of nanomedicine · 2026
    Article
  11. Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

I-Wen WuDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Yu-Chieh LiaoInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Tsung-Hsien TsaiAdvanced Tech BU, Acer Inc, New Taipei City, Taiwan.
Chieh-Hua LinInstitute of Population Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Zhao-Qing ShenDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yun-Hsuan ChanAdvanced Tech BU, Acer Inc, New Taipei City, Taiwan.
Chih-Wei TuAdvanced Tech BU, Acer Inc, New Taipei City, Taiwan.
Yi-Ju ChouInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chi-Jen LoMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Chi-Hsiao YehCommunity Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
Chun-Yu ChenDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Heng-Chih PanDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Heng-Jung HsuDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Chin-Chan LeeDepartment of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan.
Mei-Ling ChengMetabolomics Core Laboratory, Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan.
Wayne Huey-Herng SheuInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan.
Chi-Chun LaiCommunity Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
Huey-Kang SytwuNational Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli, Taiwan.
Ting-Fen TsaiDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is a serious healthcare dilemma. Nonetheless, the interplay between the functional capacity of gut microbiota and their host remains elusive for DKD. This study aims to elucidate the functional capability of gut microbiota to affect kidney function of DKD patients. A total of 990 subjects were enrolled consisting of a control group (

Indexed as

BacteriaDiabetic NephropathiesGastrointestinal MicrobiomeMachine LearningAdultAgedBiomarkersDiabetes Mellitus, Type 2FecesFemaleHumansMaleMiddle AgedRenal Insufficiency, ChronicRNA, Ribosomal, 16SBiomarkersRNA, Ribosomal, 16Sbranched-chain amino acidsDiabetic kidney diseasemachine learningmicrobiota

Identifiers

PMID40050256
PMCPMC11901534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.