Evidence map›Paper›PMID 40050429›Full record

SynthesisNature genetics2025

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.

Carolina Roselli, Ida Surakka, Morten S Olesen, Gardar Sveinbjornsson, Nicholas A Marston, Seung Hoan Choi, Hilma Holm, Mark Chaffin, Daniel Gudbjartsson, Matthew C Hill and 149 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. NovelBiomedicines · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Chromatin topology control by a muscle-specific ribosomal protein.bioRxiv : the preprint server for biology · 2026
    Article
  11. Rare TruncatingGenes · 2026
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

159 authors.

Carolina Roselli *Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Ida Surakka *Department of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-6669-5541
Morten S Olesen *Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-9477-5322
Gardar Sveinbjornsson *deCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-2429-9468
Nicholas A Marston *TIMI Study Group, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6164-4617
Seung Hoan ChoiCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2797-3190
Hilma HolmdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Mark ChaffinCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1234-5562
Daniel GudbjartssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-5222-9857
Matthew C HillCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Hildur AegisdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Christine M AlbertDepartment of Cardiology, Cedars-Sinai, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2081-1121
Alvaro AlonsoDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2225-8323
Christopher D AndersonDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Dan E ArkingMcKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8980-8695
David O ArnardeCODE genetics/Amgen Inc., Reykjavik, Iceland.
John BarnardQuantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-2403-8268
Emelia J BenjaminDepartment of Medicine, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4076-2336
Eugene BraunwaldTIMI Study Group, Boston, MA, USA.
Ben BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0002-3058-1059
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Nathalie ChamiCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8547-6424
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
Kelly ChoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.
Eue-Keun ChoiDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Ingrid E ChristophersenDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.
Mina K ChungCardiovascular Medicine, Heart Vascular and Thoracic Institute and Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
David ConenPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Harry J CrijnsDepartment of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-1073-5337
Michael J CutlerIntermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.ORCID http://orcid.org/0000-0001-9498-7472
Tomasz CzubaThe Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.ORCID http://orcid.org/0009-0001-0232-0425
Scott M DamrauerDepartment of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8009-1632
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-7471-475X
Elton DudinkDepartment of Cardiology and CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0003-4572-3969
ThuyVy DuongMcKusick Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Christian ErikstrupDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-6551-6647
Tõnu EskoInstitute of Genomics, University of Tartu, Tartu, Estonia.
Diane FatkinVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-9010-9856
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Manuel FerreiraRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-9059-1825
Daniel F FreitagBayer Pharmaceuticals, Wuppertal, Germany.
Santhi K GaneshDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3663-5249
J Michael GazianoMillion Veteran Program, VA Boston Healthcare System, Boston, MA, USA.
Bastiaan GeelhoedDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jonas GhouseDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christian GiegerResearch Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.ORCID http://orcid.org/0000-0001-6986-9554
Franco GiulianiniDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sarah E GrahamDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Vilmundur GudnasonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0002-5264-5068
Christopher HaggertyDepartment of Translational Data Science and Informatics, Geisinger, Danville, PA, USA.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7100-512X
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Kaoru ItoLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0003-1843-773X
Renee JohnsonVictor Chang Cardiac Research Institute, Sydney, New South Wales, Australia.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Sean J JurgensCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-1605-9782
Stefan KääbDepartment of Cardiology, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-8824-3581
John P KaneCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Shinwan KanyCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Maryam KavousiDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5976-6519
Shaan KhurshidCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Frederick K KamanuTIMI Study Group, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7208-1047
Paulus KirchhofDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, Hamburg, Germany.ORCID http://orcid.org/0000-0002-1881-0197
Marcus E KleberSYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.ORCID http://orcid.org/0000-0003-0663-7275
Stacey KnightIntermountain Heart Institute, Intermountain Medical Center, Murray, UT, USA.ORCID http://orcid.org/0000-0003-0092-7327
Issei KomuroInternational University of Health and Welfare, Tokyo, Japan.ORCID http://orcid.org/0000-0002-0714-7182
Jose E KriegerLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0001-5464-1792
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Dadong LiRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0868-4884
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-3043-3942
Henry J LinInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-6771-0486
Ruth J F LoosCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Luca LottaRegeneron Genetics Center, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-2619-5956
Steven A LubitzCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-9599-4866
Kathryn L LunettaDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9268-810X
Peter W MacfarlaneSchool of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK.ORCID http://orcid.org/0000-0002-5390-1596
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Rainer MalikInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Helene MantineoPrecision Cardiology Laboratory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Gregory M MarcusDivision of Cardiology, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5197-7696
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
David D McManusUniversity of Massachusetts Medical School, Worcester, MA, USA.
Olle MelanderDepartment of Internal Medicine, Lund University and Skåne University Hospital, Malmö, Sweden.
Giorgio E M MelloniTIMI Study Group, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6371-1334
Pascal B MeyreCardiovascular Research Institute Basel (CRIB), University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-1236-1386
Kazuo MiyazawaLaboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Sanghamitra MohantyTexas Cardiac Arrhythmia Institute, Austin, TX, USA.
Laia M MonfortDepartment of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Martina Müller-NurasyidIBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Navid A NafissiDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0003-0706-9548
Andrea NataleTexas Cardiac Arrhythmia Institute, Austin, TX, USA.
Saman NazarianSection of Cardiac Electrophysiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sisse R OstrowskiDepartment of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-5288-3851
Hui-Nam PakYonsei University College of Medicine, Yonsei University Health System, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-3256-3620
Shichao PangDepartment of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
Ole B PedersenDepartment of Clinical Immunology, Zealand University Hospital, Køge, Denmark.ORCID http://orcid.org/0000-0003-2312-5976
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-7782-5540
James P PirruccelloCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6088-4037
Michael PreussCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5266-8465
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology and Health Systems and Population Health, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Clive R PullingerCardiovascular Research Institute and Department of Physiological Nursing, University of California, San Francisco, CA, USA.
Daniel J RaderDivision of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Joel T RämöCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6429-5149
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-2581-070X
Lorenz RischInstitute of Laboratory Medicine, Faculty of Medical Sciences, Private University of the Principality of Liechtenstein, Triesen, Liechtenstein.ORCID http://orcid.org/0000-0003-2692-6699
Dan M RodenDepartments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-6302-0389
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID http://orcid.org/0000-0001-7191-1723
Marc S SabatineTIMI Study Group, Boston, MA, USA.
Heribert SchunkertDepartment of Cardiology, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.ORCID http://orcid.org/0000-0001-6428-3001
Svati H ShahDivision of Cardiology, Duke University School of Medicine, Durham, NC, USA.
Jaemin ShimKorea University Cardiovascular Center, Seoul, Republic of Korea.
M Benjamin ShoemakerDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Bridget SimonsonCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Moritz F SinnerDepartment of Cardiology, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-6660-796X
Roelof A J SmitCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9822-6726
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
Nicholas L SmithCardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3483-353X
J Gustav SmithThe Wallenberg Laboratory/Department of Molecular and Clinical Medicine, Institute of Medicine, Gothenburg University and the Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Elsayed Z SolimanEpidemiological Cardiology Research Center, Section on Cardiovascular Medicine, Department of Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0001-5632-8150
Erik SørensenDepartment of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5002-9077
Nona SotoodehniaDivision of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA, USA.
Daniel StrbianDepartment of Neurology and Neurosciences, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0001-9095-2344
Bruno H StrickerDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Maris Teder-LavingInstitute of Genomics, University of Tartu, Tartu, Estonia.ORCID http://orcid.org/0000-0002-5872-1850
Yan V SunDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-2838-1824
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-1893-8307
Rosa B ThorolfsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0001-7475-0398
Unnur ThorsteinsdottirdeCODE genetics/Amgen Inc., Reykjavik, Iceland.
Arnljot TveitDepartment of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.
Pim van der HarstDepartment of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Joyce van MeursDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Biqi WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Stefan WeissGerman Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-3553-4315
Quinn S WellsDepartments of Medicine Pharmacology and Biomedical Informatics, Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Lu-Chen WengCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1475-4930
Peter W WilsonDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Ling XiaoCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5463-5576
Pil-Sung YangCha University College of Medicine, Seoul, Republic of Korea.
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Zachary T YonedaDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Tanja ZellerGerman Center for Cardiovascular Research (DZHK), Hamburg, Germany.ORCID http://orcid.org/0000-0003-3379-2641
Lingyao ZengBayer Pharmaceuticals, Wuppertal, Germany.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
Xiang ZhouDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-4331-7599
Sebastian ZöllnerDepartment of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7362-156X
BioBank Japan Project
Regeneron Genetics Center
DBDS Genomic Consortium
Christian T RuffTIMI Study Group, Boston, MA, USA.
Henning BundgaardDepartment of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark.
Cristen WillerDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-5645-4966
Kari StefanssondeCODE genetics/Amgen Inc., Reykjavik, Iceland.ORCID http://orcid.org/0000-0003-1676-864X
Patrick T EllinorCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ellinor@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-2067-0533

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Ethnic/Racial Variation in Intracerebral Hemorrhage (ERICH)U01NS069763 · NINDS · UNIVERSITY OF CINCINNATI · PI ANDERSON, CHRISTOPHER DAVID, DEMEL, STACIE · 2010 to 2024
$34.2M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
American Heart Association-American Stroke Association 16EIA26410001American Heart Association-American Stroke Association 18SFRN34110067American Heart Association-American Stroke Association 18SFRN34110082American Heart Association-American Stroke Association 18SFRN34250007BLRD VA I01 BX004821BLRD VA IK6 BX006185CSRD VA IK2 CX001780NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR024989NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01 HG007417NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200782096CNHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL159346NHLBI NIH HHS K23 HL169839NHLBI NIH HHS K24 HL148521NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS P01 HL158502NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL068986NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL095080NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL157635NHLBI NIH HHS R01 HL158071NHLBI NIH HHS R01 HL172803NHLBI NIH HHS R35 HL161016NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS N01 AG012100NIA NIH HHS R01 AG023629NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG009740NIDA NIH HHS HHSN271201200022CNIDDK NIH HHS P30 DK063491NINDS NIH HHS R01 NS103924NINDS NIH HHS U01 NS069208NINDS NIH HHS U01 NS069763
6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart failure and stroke. This large-scale meta-analysis of genome-wide association studies increased the power to detect single-nucleotide variant associations and found more than 350 AF-associated genetic loci. We identified candidate genes related to muscle contractility, cardiac muscle development and cell-cell communication at 139 loci. Furthermore, we assayed chromatin accessibility using assay for transposase-accessible chromatin with sequencing and histone H3 lysine 4 trimethylation in stem cell-derived atrial cardiomyocytes. We observed a marked increase in chromatin accessibility for our sentinel variants and prioritized genes in atrial cardiomyocytes. Finally, a polygenic risk score (PRS) based on our updated effect estimates improved AF risk prediction compared to the CHARGE-AF clinical risk score and a previously reported PRS for AF. The doubling of known risk loci will facilitate a greater understanding of the pathways underlying AF.

Indexed as

Atrial FibrillationGenetic Predisposition to DiseaseGenome-Wide Association StudyMultifactorial InheritanceChromatinHumansMyocytes, CardiacPolymorphism, Single NucleotideRisk FactorsChromatin

Identifiers

PMID40050429
PMCPMC12094172

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.