SynthesisBMC anesthesiology2025
Unraveling the impact of frailty on postoperative delirium in elderly surgical patients: a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Effect of Ciprofol on Postoperative Cognitive Function in Patients Undergoing Cardiac Surgery with Cardiopulmonary Bypass: A Prospective, Randomized, Controlled Trial.Drug design, development and therapy · 2025Trial
- Serum C1q as a Novel Predictive Biomarker for Postoperative Delirium After Acute Type A Aortic Dissection.Immunity, inflammation and disease · 2026Article
- Article
- Association of preoperative frailty and delayed neurocognitive recovery in older adults undergoing major elective surgery in Thailand: a single centre prospective study.The Lancet regional health. Southeast Asia · 2026Article
- Article
- Development of a machine learning-based prediction model for postoperative delirium in frail elderly patients undergoing noncardiac surgery under general anesthesia.European geriatric medicine · 2026Article
- Observational
- Precision Sedation for Gastrointestinal Endoscopy in Older Adults: Brain Vulnerability and Recovery.Drug design, development and therapy · 2026Review
- Postoperative delirium risk in elderly high-risk patients undergoing hip and knee arthroplasty (ASA Ⅲ-Ⅳ): construction and validation of a nomogram model based on frail frailty index.Frontiers in medicine · 2026Article
- Impact of anesthesia methods on adverse cardiovascular events during painless gastroscopy in frail older patients: study protocol for a prospective controlled trial.Frontiers in medicine · 2026Article
- Frailty in older adults with chronic obstructive pulmonary disease: preliminary findings of prevalence and care priorities.BMC geriatrics · 2025Article
- The dynamic nature of frailty in metastatic spine disease patients.Journal of neuro-oncology · 2025Article
- Delirium after surgery: a retrospective study of predictors, complications, and screening patterns in the national surgical quality improvement program.EClinicalMedicine · 2025Article
- Post-Operative Delirium in Elderly Patients: A Narrative Review.International journal of molecular sciences · 2025Review
- Preoperative Anesthesia Assessment in Elderly Patients: Challenges and Opportunities for Safer Perioperative Care.Cureus · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrailty has been consistently implicated as a pivotal factor in the onset of delirium following anesthesia and surgery. Nonetheless, a comprehensive understanding of the relationship between frailty and delirium remains to be elucidated. This study addresses that knowledge gap.
methodsA comprehensive search of literature databases identified 43 relevant studies involving 14,441 participants. The studies were subjected to a rigorous quality assessment using the Newcastle-Ottawa Scale. Statistical analysis was conducted using Review Manager (v5.4.1), including subgroup and sensitivity analyses.
resultsMeta-analysis revealed a significant association between preoperative physical frailty and postoperative delirium (pooled odds ratio: 2.47; 95% confidence interval: 2.04-2.99; I
conclusionsFuture research could focus on optimizing the integration of frailty assessment into preoperative protocols for timely intervention and improved patient outcomes.
trial registrationThe review protocol was registered with PROSPERO (CRD42023390486), date of registration: Aug 11, 2023.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.