ArticleBMC medical imaging2025
Analysis of features of papillary thyroid carcinoma on color Doppler ultrasound images: implications for lymph node metastasis.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A comparative analysis of clinical and sonographic features: cutaneous melanoma and melanocytic nevi.Translational cancer research · 2026Article
- Predictive value of conventional ultrasonographic features combined with clinical factors for capsular invasion in papillary thyroid carcinoma with Hashimoto's thyroiditis.American journal of cancer research · 2026Article
- Clinicopathological Significance of Ultrasound Risk Features and the Taller-Than-Wide Sign for Tumor Advancement in Differentiated Thyroid Cancer: A Single-Center Analysis.Cancer management and research · 2026Article
- High-frequency ultrasound combined with superb microvascular imaging for differential diagnosis of basal cell carcinoma and seborrheic keratosis: a retrospective analysis with nomogram implementation.Frontiers in medicine · 2026Article
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8 authors.
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Abstract
backgroundThis study aimed to describe the color Doppler flow features of papillary thyroid carcinoma (PTC) and to further investigate the associations between these features and lymph node metastasis (LNM).
methodsA retrospective analysis of the clinical data of 287 PTC patients confirmed by postoperative pathology at the Second Affiliated Hospital of Xi'an Jiaotong University from January 2022 to April 2023 was conducted. The Adler grading system and novel blood flow patterns were used to analyze the vascularity of the PTC lesions on color Doppler images. Univariate and multivariate logistic regression analyses were conducted to evaluate the independent effects of blood flow characteristics on LNM, and a logistic regression model was established to assess their predictive value for PTC-related LNM.
resultsIn all, 287 PTC lesions were analyzed using color Doppler ultrasonography, which identified five main reference patterns: avascular (26.13%), dot-line (24.74%), branching (14.29%), garland (11.50%), and rich-disorganized (23.34%). The Adler blood flow grading was as follows: 0 (32.75%), I (18.82%), II (19.16%), and III (29.27%). A univariate analysis revealed that the Adler grade was not significantly associated with LNM (P > 0.05), whereas the garland pattern was significantly associated with LNM (P < 0.05). A multivariate analysis revealed that the garland pattern was an independent protective factor for LNM (OR [95% CI] = 0.386 [0.156-0.893]). The incorporation of the garland pattern into the model improved the predictive accuracy for LNM in PTC patients, and the AUC increased from 0.727 [95% CI: 0.669-0.786] to 0.767 [95% CI: 0.731-0.821].
conclusionsThis study classifies PTC into five types on the basis of color Doppler flow features and highlights the garland pattern as a potential predictor of LNM risk.
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