ArticleBMC public health2025
Association of neutrophil to high density lipoprotein cholesterol ratio with aortic dissection and aneurysm risk: epidemiological insights from prospective cohort study based on UK biobank.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Association Between Neutrophil-to-High-Density Lipoprotein-Cholesterol Ratio and Coronary Artery Calcium: A Cross-Sectional Study.Biomedicines · 2026Article
- The relationship of neutrophil to high-density lipoprotein cholesterol ratio with all-cause mortality in patients undergoing cardiac surgery: a retrospective cohort study.Journal of cardiothoracic surgery · 2026Article
- Type 2 diabetes mellitus and incident carotid atherosclerosis: a retrospective cohort study on composite indices.Frontiers in endocrinology · 2026Article
- Admission neutrophil-to-high-density lipoprotein cholesterol ratio and the risk of preoperative early rebleed in aneurysmal subarachnoid hemorrhage.European journal of medical research · 2025Article
- Systemic inflammatory and metabolic indexes for aortic dissection: a machine learning analysis.BMC cardiovascular disorders · 2025Article
- Association between atherogenic index of plasma and incident aortic disease: a population-based prospective analysis.Open heart · 2025Observational
- Association between neutrophil-to-HDL cholesterol ratio and the risk of gout or hyperuricemia: evidence from NHANES 2007-2018.European journal of medical research · 2025Article
- Neutrophil-to-High density lipoprotein cholesterol ratio predicts early hematoma expansion in patients with spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- Association between neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and psoriasis risk: a nationally representative cross-sectional study.Frontiers in immunology · 2025Article
- Evaluation of perivascular fat density and residual false lumen formation following TEVAR in Stanford type B aortic dissection.Frontiers in cardiovascular medicine · 2025Article
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Abstract
backgroundNeutrophil to high-density lipoprotein cholesterol ratio (NHR) is a metabolic inflammatory biomarker reflecting the balance between pro- and anti-inflammatory responses. Extensive research has revealed that NHR is an effective predictor for cardiovascular risks, such as stroke and myocardial infarction. Nevertheless, the association between NHR and incidence risks of aortic dissection (AD) and aortic aneurysm (AA) remains unclear.
methodsThis research, designed as a prospective cohort study, enrolled 409,357 participants based on the UK Biobank project. The cut-off value of NHR i.e., 0.205, was determined using a receiver operating characteristic curve for grouping. Participants were divided into two groups: NHR ≤ 0.205 (n = 293,294) and NHR > 0.205 (n = 116,063). The cumulative incidence of outcome, i.e., AD/AA including AD and AA, was calculated using Kaplan-Meier curves. The dose-response relationship between NHR and AD/AA was evaluated using restricted cubic spline (RCS). Multivariable-adjusted Cox proportional hazards regression models, followed by sensitivity analyses and subgroup analyses, were performed to evaluate the association between NHR and AD/AA onset.
resultsA total of 3,408 participants developed AD/AA, including 233 AD cases and 3,259 AA cases, with a median follow-up period of 14.8 years. The incidences of AD/AA, AD and AA were 56.34, 3.85 and 53.87 cases per 100,000 person-years, respectively. A nonlinear relationship between NHR and the incidence risk of AD/AA was documented by RCS (P for nonlinear < 0.001). Participants in the NHR > 0.205 group had a higher risk of developing AD/AA compared to those in the NHR ≤ 0.205 group, with an adjusted HR of 1.47 (95%CI 1.37-1.58). This association was further validated by sensitivity analyses and subgroup analyses.
conclusionsNHR is an independent risk factor for AD/AA. The disorder of metabolic inflammation may be a potential pathological mechanism for AD/AA. Tailored assessment and management of NHR may serve as effective strategies for the prevention and prediction of AD/AA.
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