ArticleLipids in health and disease2025
Systemic inflammation partially mediates the association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and chronic cough.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Article
- Observational
- Article
- Remnant cholesterol inflammatory index and MASLD in U.S. adults: mediation role of triglyceride-glucose index.Journal of clinical & translational endocrinology · 2026Article
- Remnant cholesterol and lipid ratios predict the relapse of neuromyelitis optica spectrum disorder.Lipids in health and disease · 2026Article
- Association of the high-density lipoprotein cholesterol to C-reactive protein ratio with chronic cough in US adults: Effect modification by smoking status.Tobacco induced diseases · 2026Article
- Female predominance in chronic cough: biological sex-related factors, mechanisms, and therapeutic targets-a narrative review.Frontiers in medicine · 2026Review
- Association between heavy metal exposure and chronic cough: the mediating roles of inflammation.Annals of medicine · 2025Article
- The association between systemic inflammation, lung function and respiratory symptoms in the BOLD study in Northern Europe.Scientific reports · 2025Article
- Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Utility of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio in individuals with retinal vein occlusion.Frontiers in cardiovascular medicine · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundNon-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), a new biomarker, reflects blood lipid status. Nevertheless, the association between NHHR and chronic cough remains uncertain.
methodThis investigation included 9725 individuals from the NHANES. This research employed multiple statistical models to illustrate the association between NHHR and chronic cough. These models included logistic regression models, the Shapley Additive Explanations (SHAP) model, trend tests, mediation analysis, restricted cubic splines (RCS), and subgroup analyses.
resultThe logistic regression model, adjusting all covariables, showed a positive association between NHHR with chronic cough (OR: 1.08; 95% CI: 1.02-1.14). Trend tests and RCS further proved that NHHR and chronic cough had a linear and positive association. The mediation analysis proved that systemic immune inflammation index (SII) and systemic inflammatory response index (SIRI) partially mediated the association between NHHR and chronic cough. The SHAP model suggested that the top five important markers for predicting chronic cough were SII, smoking, NHHR, BMI, and SIRI.
conclusionThis investigation discovered that NHHR was positively associated with chronic cough. Regular NHHR monitoring may serve as a potential tool for identifying individuals at higher risk of chronic cough.
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