ArticleAdvanced healthcare materials2025
Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- An NIR-responsive FeS-loaded alginate hydrogel promotes diabetic wound healing through Nrf2 activation and macrophage polarization.International journal of pharmaceutics: X · 2026Article
- Astaxanthin-metformin conjugate nanomicelles-loaded hydrogel reprograms macrophage metabolismBioactive materials · 2026Article
- Carbon quantum dot incorporated AV/carboxymethyl cellulose hydrogel for enhanced wound healing.RSC advances · 2026Article
- Multi-Functional Adaptive Interfaces for Next-Generation Wearable and Implantable Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A ROS-responsive core-shell microneedle platform integrating sonodynamic gas antibacterial therapy and modulating immunity for diabetic wound healing.Journal of nanobiotechnology · 2026Article
- Material-driven glucose responsiveness in insulin delivery systems: carrier selection and performance.Frontiers in endocrinology · 2026Review
- Microenvironment self-adaptive multifunctional hydrogels elicit immunomodulation mediated wound healing.Materials today. Bio · 2025Article
- Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound.Advanced healthcare materials · 2025Article
- ROS-triggered hydrophilicity switching synergizes with pH-responsive nanocarriers for therapy of diabetic wound.Regenerative biomaterials · 2025Article
- A catechol-modified quaternized chitosan/PEG hydrogel for diabetic wound healing: synergistic effects of TGF-β3 delivery, angiogenesis, and antibacterial activity.Frontiers in cellular and infection microbiology · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Hydrogels are soft, tissue-like materials that have great potential as wound dressings. However, most hydrogels are unsatisfactory in achieving whole-layer regeneration of diabetic wounds due to the complex pathological microenvironment and irregular wound shapes. Here, a glucose-responsive and self-adaptive phenylboronic acid (PBA) hydrogel solubilized strong antioxidant flavonoids (Gel-Flavonoids) is developed via dynamic borate bonds. The Gel-Flavonoids system can spontaneously confirm to the irregular wound shape and release flavonoids in a high-glucose microenvironment to effectively eliminate reactive oxygen species (ROS). The optimized Gel-Flavonoids demonstrate remarkable efficacy in inhibiting inflammation and activating fibroblasts and endothelial cells through CD36-activated lipid metabolism in macrophages and is significantly superior to commercial dressings (3M) in healing rate (> 93%, 14 days) and whole-layer regeneration effect. This study obtained a multidimensional Gel-Flavonoids system to effectively repair diabetic wounds, and reveal the underlying therapeutic mechanisms, offering a promising insight to guide the development of medical materials to treat diabetic wounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.