ArticleFrontiers in public health2025
Association of metabolic score for insulin resistance with incident metabolic syndrome: a cohort study in middle-aged and older adult Chinese population.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Development and validation of a predictive model for the severity of hyperlipidemic acute pancreatitis based on the bedside index for severity in acute pancreatitis and metabolic score for insulin resistance: A retrospective cohort study.The Journal of international medical research · 2026Article
- Dietary quality, insulin resistance, and preserved ratio impaired spirometry in postmenopausal women: a cross-sectional study with exploratory mediation analysis.Frontiers in nutrition · 2026Article
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14 authors.
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Abstract
Background: Recent studies suggest that the metabolic score for insulin resistance (MetS-IR) is an effective indicator of metabolic disorders. However, evidence on the relationship between MetS-IR and metabolic syndrome (MetS) among the Chinese middle-aged and older adult population is limited. Objective: This cohort study aims to assess the associations of MetS-IR levels with MetS risk and its components. Methods: Data used in this study from the National Basic Public Health Service Project Management System (2020-2023). Multivariable Cox proportional hazards model and restricted cubic spline (RCS) were employed to evaluate the associations of baseline MetS-IR levels with MetS risk and its components, receiver operating characteristic (ROC) curves were further utilized to assess the efficacy of MetS-IR in predicting the risk of MetS and its component. Results: Of 1,498 subjects without MetS at baseline, 392 incident MetS cases were observed during a median of 27.70 months of follow-up. The adjusted multivariable Cox regression analysis indicated an elevated 15% risk of developing MetS for 1-SD increment of MetS-IR [hazard ratios (HRs) and 95% confidence intervals: 1.16 (1.13-1.18)]. Compared to the first tertile of MetS-IR, the HRs of the third tertile and second tertile were 6.31 (95% CI 4.55-8.76) and 2.72 (95% CI 1.92-3.85), respectively. Consistent findings were further detected across subgroups. Moreover, nonlinear associations were observed between MetS-IR and the risk of MetS, abdominal obesity, and reduced high-density lipoprotein concentration (HDL-C) ( Conclusion: Our cohort study indicates a positive nonlinear association between MetS-IR with incident MetS, abdominal obesity, and reduced HDL-C, but positive linear associations of MetS-IR and elevated blood pressure (BP), elevated fasting blood glucose (FBG), elevated triglycerides (TG) in middle-aged and older adult people, more studies are warranted to verify our findings.
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