ArticleThe Journal of biological chemistry2025
Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting Na
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Article in The Journal of biological chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
–field-weighted citation impact
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Ursula Ravens - recipient of the Schmiedeberg Medal: a distinguished career dedicated to cardiovascular pharmacology and cardiac electrophysiology.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Lorena Camargo-AyalaDoctorado en Ciencias Mención I + D de Productos Bioactivos, Instituto de Química de Recursos Naturales, Laboratorio de Síntesis Orgánica, Universidad de Talca, Talca, Chile.
Mauricio BedoyaCentro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca, Chile; Laboratorio de Bioinformática y Química Computacional (LBQC), Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile.
Albert DasíDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.
Merten PrüserDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany.
Sven SchütteInstitute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Luis Prent-PeñalozaDepartamento de Ciencias Químicas, Facultad de Ciencias Exactas, Universidad Andrés Bello, Viña del Mar, Chile.
Francisco Adasme-CarreñoCentro de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca, Chile; Laboratorio de Bioinformática y Química Computacional (LBQC), Departamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile.
Aytug K KiperInstitute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany; Institute of Physiology, University Medicine Greifswald, Greifswald, Germany.
Susanne RinnéInstitute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany.
Paola Andrea Camargo-AyalaDoctorado en Ciencias Biomédicas, Laboratorio de Patología Molecular, Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca, Talca, Chile.
Paula A Peña-MartínezDoctorado en Ciencias Agrarias, Facultad de Ciencias Agrarias, Universidad de Talca, Talca, Chile; Laboratorio de Química Enológica, Facultad de Ciencias Agrarias, Universidad de Talca, Talca, Chile.
Alfonso Bueno-OrovioDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.
Diego VarelaMillennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Santiago, Chile; Program of Physiology and Biophysics, Institute of Biomedical Sciences, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Felix WiedmannDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany.
José C E Márquez MontesinosCentro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, Chile; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
Yuliet MazolaCentro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, Chile; Centro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
Whitney VenturiniDepartamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca, Chile.
Rafael ZúñigaCentro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
Leandro ZúñigaCentro de Nanomedicina, Diagnóstico y Desarrollo de Fármacos (ND3), Laboratorio de Fisiología Molecular, Escuela de Medicina, Universidad de Talca, Talca, Chile.
Constanze SchmidtDepartment of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), partner site Heidelberg /Mannheim, University of Heidelberg, Heidelberg, Germany; HCR, Heidelberg Center for Heart Rhythm Disorders, University of Heidelberg, Heidelberg, Germany.
Blanca RodriguezDepartment of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK.
Ursula RavensGerman Atrial Fibrillation Competence NETwork (AFNET), Freiburg, Germany; Institute of Experimental Cardiovascular Medicine, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg and Faculty of Medicine, Freiburg, Germany.
Niels DecherInstitute for Physiology and Pathophysiology, Philipps-University Marburg, Marburg, Germany. Electronic address: decher@staff.uni-marburg.de.
Margarita GutiérrezLaboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca, Talca, Chile. Electronic address: mgutierrez@utalca.cl.
Wendy GonzálezMillennium Nucleus of Ion Channels-Associated Diseases (MiNICAD), Santiago, Chile; Centro de Bioinformática, Simulación y Modelado (CBSM), Universidad de Talca, Talca, Chile. Electronic address: wgonzalez@utalca.cl.
Funding
Wellcome Trust
Abstract
Atrial fibrillation (AF) involves electrical remodeling of the atria, with ion channels such as Na
Indexed as
Anti-Arrhythmia AgentsAtrial FibrillationDrug DesignKv1.5 Potassium ChannelNAV1.5 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPotassium Channel BlockersPotassium Channels, Tandem Pore DomainAction PotentialsHumansMyocytes, CardiacAnti-Arrhythmia AgentsKCNA5 protein, humanKv1.5 Potassium ChannelNAV1.5 Voltage-Gated Sodium ChannelNerve Tissue ProteinsPotassium Channel BlockersPotassium Channels, Tandem Pore Domainpotassium channel subfamily K member 3SCN5A protein, humanatrial fibrillationion channelsK(2)P channelsK(V)1.5multi-target inhibitorsNa(V)1.5Polypharmacology
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.