Evidence map›Paper›PMID 40055244›Full record

ArticleArchives of osteoporosis2025

Weaker subchondral bone and thinner articular cartilage of the knee are associated with elevated baseline fracture risk independently of osteoarthritis risk factors.

Andy K O Wong, Anthony Pokhoy, Ali M Naraghi, Rakesh Mohankumar

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Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andy K O WongJoint Department of Medical Imaging, University Health Network, Toronto, ON, Canada. andy.wong@uhn.ca.
Anthony PokhoyJoint Department of Medical Imaging, University Health Network, Toronto, ON, Canada.
Ali M NaraghiJoint Department of Medical Imaging, University Health Network, Toronto, ON, Canada.
Rakesh MohankumarJoint Department of Medical Imaging, University Health Network, Toronto, ON, Canada.

Funding

Arthritis Society 21-0035Institute of Musculoskeletal Health and Arthritis PJT-156274Institute of Musculoskeletal Health and Arthritis PJT-166012
6 · The paper itself

Abstract

Knee osteoarthritis involves damaged bones beneath joint surfaces but how current bone health predicts future disease state is unclear. We discovered higher osteoporotic fracture risk (FRAX) was linked to compromised knee bone quality and thinner cartilage. Integrating FRAX into osteoarthritis care could identify who may develop worse disease outcomes.

objectivesTo examine how well fracture risk predicts subchondral bone and cartilage morphometry independently of osteoarthritis (OA) clinical risk factors.

methodsMale and female participants in the Osteoarthritis Initiative (OAI) at visit 5 (36 months) were evaluated for fracture risk using FRAX and categorized into low-, moderate-, or high-risk groups. These groups were compared for bone marrow lesion (BML) size, number and effusion, subchondral bone structure, density, and cartilage morphometry in the most affected knee at either same time point, 1 or 2 years later, using general linear models. Sex interactions were examined in each case and probed if significant.

resultsAmong 1240 participants (58.8% female, age: 63.7 ± 8.8 years, and BMI: 30.1 ± 4.9 kg/m

conclusionsHigh FRAX predicts thinner cartilage and weaker subchondral bone within a year. Complementing standard OA clinical risk factors with FRAX calculation could help identify individuals likely to develop worse knee OA radiologic outcomes.

Indexed as

Cartilage, ArticularKnee JointOsteoarthritis, KneeOsteoporotic FracturesAgedBone DensityFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsBMDBone marrow lesionCartilage morphometryFracture riskFRAXKnee osteoarthritisMRISubchondral bone structure

Identifiers

PMID40055244

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.