Evidence map›Paper›PMID 40055463›Full record

ArticleScientific reports2025

Effects of reduced extracellular sodium on proliferation and invasive activity of renal cell carcinoma cell lines.

Laura Naldi, Martina Catalano, Maria Elena Melica, Simone Polvani, Dimitri Papini, Ida Landini, Alessandro Peri, Giandomenico Roviello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Laura Naldi *Endocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy.
Martina Catalano *Department of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, 50139, Florence, Italy.
Maria Elena Melica *Nephrology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy.
Simone PolvaniGastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy.
Dimitri PapiniGastroenterology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy.
Ida LandiniDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, 50139, Florence, Italy.
Alessandro PeriEndocrinology Unit, Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Florence, 50139, Florence, Italy. alessandro.peri@unifi.it.ORCID http://orcid.org/0000-0001-6417-434X
Giandomenico RovielloDepartment of Health Sciences, Section of Clinical Pharmacology and Oncology, University of Florence, 50139, Florence, Italy.

Funding

European Union - Next Generation EU. National Recovery and Resilience Plan (PNRR) Mission 4, Component 2 - Investment 1.4 - CUP B13C22001010001Research Grant from the University of Florence RICATEN2023
6 · The paper itself

Abstract

Hyponatremia is the most common electrolyte disorder in cancer patients and is associated with a worse outcome. This finding has also been reported in patients with metastatic renal cell carcinoma (mRCC). We have previously demonstrated that low extracellular sodium concentrations ([Na

Indexed as

Carcinoma, Renal CellCell ProliferationKidney NeoplasmsSodiumCell Line, TumorCell MovementHumansNeoplasm InvasivenessNF-E2-Related Factor 2Reactive Oxygen SpeciesNFE2L2 protein, humanNF-E2-Related Factor 2Reactive Oxygen SpeciesSodiumHyponatremiaKidney cancerRenal cell carcinoma cell linesSodium

Identifiers

PMID40055463
PMCPMC11889168

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.