ArticleNature genetics2025
Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex.
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed.
- Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.bioRxiv : the preprint server for biology · 2026Article
- Ultra-Fast Implementation of Multivariate GWAS in Genomic SEM Using Flexible Analytic Estimation.bioRxiv : the preprint server for biology · 2026Article
- Personality Genomics.Annual review of psychology · 2026Review
- Distinguishing specific from broad genetic associations between external correlates and common factors.Bioinformatics (Oxford, England) · 2025Article
- Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity.medRxiv : the preprint server for health sciences · 2025Article
- Temperament multi-trajectory groups across adolescence: Associations with adulthood psychopathology and polygenic scores in TRAILS.Development and psychopathology · 2025Article
- Distinguishing Specific from Broad Genetic Associations between External Correlates and Common Factors.bioRxiv : the preprint server for biology · 2025Article
- Article
- Tradeoffs in Modeling Context Dependency in Complex Trait Genetics.bioRxiv : the preprint server for biology · 2025Article
- Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2025Article
- The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis.Molecular autism · 2024Article
- Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts.JAMA psychiatry · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Differences in the patterning of genetic sharing between groups of individuals may arise from biological pathways, social mechanisms, phenotyping and ascertainment. We expand genomic structural equation modeling to allow for testing genomic structural invariance (GSI), that is, the formal comparison of multivariate genetic architecture across groups. We apply GSI to compare the autosomal multivariate genetic architecture of eight psychiatric disorders spanning three factors (psychotic, neurodevelopmental and internalizing) between cisgender males and females. We find that the genetic factor structure is largely similar across sex, permitting meaningful comparisons of associations at the level of the factors. However, in females, problematic alcohol use and posttraumatic stress disorder loaded more strongly on the internalizing factor, while the neurodevelopmental disorder factor exhibited weaker genetic correlations with the other factors. Four phenotypes (educational attainment, insomnia, smoking and deprivation) showed significant, albeit small, sex-differentiated associations with the psychotic factor. As genome-wide association study samples grow and diversify, GSI will become increasingly valuable for comparing multivariate genetic architecture across groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.