ArticleBMC geriatrics2025
Red blood cell distribution width to albumin ratio (RAR) is associated with low cognitive performance in American older adults: NHANES 2011-2014.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Association of the red blood cell distribution width-to-albumin ratio with incident depression and depressive symptom trajectories in older adults.European archives of psychiatry and clinical neuroscience · 2026Article
- Preoperative RDW-Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery.Cancer medicine · 2026Article
- Red blood cell distribution width-to-albumin ratio and osteoarthritis: A cross-sectional and cohort study.The Journal of international medical research · 2026Article
- Article
- Rest-activity rhythms and cardiovascular events in cardiovascular-kidney-metabolic syndrome: evidence from two nationwide cohorts.American journal of preventive cardiology · 2026Article
- Red blood cell distribution width to albumin ratio and cancer prognosis in U.S. adults: NHANES 2005 to 2016.Medicine · 2026Article
- The Relationship of the Red Cell Distribution Width-to-Albumin Ratio and Other Inflammatory Markers With Cataracts: An Analysis of the NHANES Population.Translational vision science & technology · 2026Article
- The association between red blood cell distribution width-to-albumin ratio andFrontiers in nutrition · 2026Article
- Association of red cell distribution width-to-albumin ratio with mortality in adults with low muscle mass: A retrospective cohort study.The Journal of international medical research · 2026Article
- Development and Validation of a Neutrophil Percentage-to-Albumin Ratio-Based Nomogram for Predicting Overall Survival in Locally Advanced Nasopharyngeal Carcinoma.Journal of inflammation research · 2026Article
- Association between red cell distribution width/serum albumin ratio and Parkinson's disease.European journal of medical research · 2025Article
- The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from two cohort studies.Cardiovascular diabetology · 2025Article
- Red blood cell distribution width-to-albumin ratio and its association with age-related macular degeneration: a population-based cross-sectional study.Frontiers in medicine · 2025Article
- Hemoglobin-to-red blood cell distribution width ratio: a new insight into cognitive protection for obese individuals.Frontiers in medicine · 2025Article
- Association of blood urea nitrogen to albumin ratio with cerebral small vessel disease and its ischemic imaging markers: a cross-sectional study.Frontiers in neurologyArticle
- The association between red blood cell distribution width to albumin ratio and migraine: evidence from clinical and population-based cohorts.Frontiers in neurologyArticle
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8 authors.
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Abstract
backgroundThe red blood cell distribution width to albumin ratio (RAR) is a novel comprehensive biomarker of inflammation and nutrition, which has emerged as a reliable prognostic indicator for adverse outcomes and mortality in patients with various diseases. However, the association between RAR and low cognitive performance in older adults remains unclear. This study aims to investigate the relationship between RAR and low cognitive performance among older adults in the United States.
methodsThis study, a retrospective analysis, included 2,765 participants aged 60 years and older from the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2014. Low cognitive performance was assessed using word learning subset from the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), the Digit Symbol Substitution Test (DSST), and the Animal Fluency Test (AFT). Low cognitive performance was defined as scores below the lowest quartile in each cognitive test. The association between RAR and low cognitive performance was evaluated using weighted multivariable logistic regression, restricted cubic splines (RCS), and subgroup analyses.
resultsAfter adjusting for all potential confounders, RAR was independently and linearly positively associated with both low DSST performance and low AFT performance. Specifically, compared to participants in the first quartile of RAR, those in the fourth quartile had adjusted ORs (95% CIs) of 1.81 (1.03, 3.20) for low DSST performance and 1.68 (1.05, 2.67) for low AFT performance. Subgroup analysis did not reveal significant interactions between stratification variables.
conclusionRAR is significantly linearly positively associated with low cognitive performance. Maintaining a lower RAR may be a crucial strategy for mitigating the risk of cognitive decline in the elderly population.
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