ArticleBMC neurology2025
Causal relationship between Baff-R expression and normal pressure hydrocephalus: insights from Mendelian randomization analysis.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
objectivesPrevious studies have suggested a possible link between normal pressure hydrocephalus (NPH) and immune factors, but the causal relationship between NPH and Baff-R expression on immune cells remains enigmatic. This study used a Mendelian randomization (MR) method to elucidate this association.
methodsThe study used data from the Finngen genome-wide association study (GWAS) and included a large European cohort of 767 patients with NPH and 375,610 controls. Baff-R genetic results in 3,757 individuals of European ancestry had 22 Baff-R-related traits. Different MR techniques were used, and efficacy was assessed using heterogeneity and sensitivity analyses. RESULTS AND
conclusionAmong the 22 traits, 8 Baff-R-related traits were causally related to NPH. The genetic prediction indicates that Baff-R, particularly in the area of BAFF - R on unswitched memory B cell, BAFF - R on IgD + CD38 - B cell, BAFF - R on CD24 + CD27 + B cell, BAFF - R on IgD - CD38 - B cell, BAFF - R on IgD + CD38dim B cell, BAFF - R on IgD + CD24 + B cell, BAFF - R on IgD + CD38 - naive B cell, BAFF - R on memory B cell may decrease risks on the development of NPH. These findings may help us to understand the immune mechanisms associated with NPH and help to develop future biomarkers related to the disease.
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