Evidence map›Paper›PMID 40055693›Full record

ReviewCancer cell international2025

Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer.

Lijie Zhang, Xiaomin Zhao, Xianghong Gao, Hao Qin, Feng Chen, Zhijuan Lin

Abstract readReview
In one paragraph

Review in Cancer cell international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lijie ZhangKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Xiaomin ZhaoKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Xianghong GaoKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Hao QinKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China.
Feng ChenWeifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, 261001, Shandong, China. 15610279319@163.com.
Zhijuan LinKey Laboratory for Immunology in Universities of Shandong Province, School of Basic Medicine Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, China. eva1949@163.com.

Funding

National Natural Science Foundation of China 32000495National Natural Science Foundation of Shandong Province ZR2020MH202the Weifang Science and Technology Development Plan Project No. 2024YX039
6 · The paper itself

Abstract

High mobility group A1 (HMGA1) is a class of non-histone chromosomal protein and is highly expressed in the embryonic period and many tumors. It is involved in multiple hallmarks of tumors and affects the occurrence and progression of tumors. Nowadays, many non-coding RNAs (ncRNAs), such as miRNA, lncRNA, and circRNA, have been found to play a crucial role in HMGA1 regulation. Moreover, some ncRNAs are reported to be the downstream effectors of HMGA1. They interact with each other to affect multiple hallmarks of cancer and targeting ncRNAs or HMGA1 may provide potential strategies for cancer therapy. In this review, we give an overview of recent studies describing the crosstalk between oncogenic HMGA1 and ncRNAs. We also point out the impact of this interaction on the biological behavior of tumors and their potential in tumor therapy in order to offer potential implications and directions for both basic science and clinical applications.

Indexed as

CircRNAHMGA1LncRNATargeted therapyTumorigenesis

Identifiers

PMID40055693
PMCPMC11887209

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.