Evidence map›Paper›PMID 40055819›Full record

ArticleJournal of nanobiotechnology2025

Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy.

Suai Lin, Tiehan Cui, Yuxin Jiang, Jialiang Xie, Da Zhong, Junkai Jiang, Dan Deng, Mengzhen Zhao, Chengzhou Xue, Shiyu Gan and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suai LinDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.
Tiehan Cui *Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.
Yuxin Jiang *The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Jialiang XieThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Da ZhongThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Junkai JiangDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.
Dan DengThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Mengzhen ZhaoThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Chengzhou XueThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Shiyu GanThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China.
Jiaxuan QiuDepartment of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China. qiujiaxuan@163.com.
Xiaolei WangThe National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, P. R. China. wangxiaolei@ncu.edu.cn.

Funding

Jiangxi Province Key Laboratory of bioengineering drugs 2024SSY07061the Graduate Innovation Special Fund Projects of Jiangxi Province YC2023-B052the Interdiscipline Innovation Fund Project of Nanchang University PYJX20230001the Jiangxi Natural Science Foundation 20232BAB216073the Key Projects of Jiangxi Administration of Traditional Chinese Medicine GZY-KJS-2023-028the Key Research and Development Program of Jiangxi Province 20212BBG73004the Key Research and Development Program of Science and Technology Department of Jiangxi Province 20212BBG71005the National Natural Science Foundation of China 82260194the Science and Technology Innovation Base Construction Project of Science and Technology Department of Jiangxi Province 20221ZDG020068
6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need to be taken simultaneously: localizing the diseased area, improving the anaerobic microenvironment, as well as addressing the anti-inflammatory and osteogenic needs. This study aims to address these issues by developing a responsive near-infrared-IIb nanozyme system (DMUP), assembled from lanthanide-doped down-converted nanoparticles and multi-enzymatically active nanozyme. DMUP binds to bacterial membranes via the bacterial targeting peptide ubiquicidin

Indexed as

Anti-Bacterial AgentsBacteria, AnaerobicNanoparticlesPeriodontitisAnimalsHumansManganeseMiceRAW 264.7 CellsReactive Oxygen SpeciesAnti-Bacterial AgentsManganeseReactive Oxygen SpeciesAnti-anaerobicAnti-inflammationAutophagyNear-infrared-IIb region imagingPeriodontitis

Identifiers

PMID40055819
PMCPMC11889803

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.