Evidence map›Paper›PMID 40055821›Full record

ArticleArthritis research & therapy2025

Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity.

Sangmee Sharon Bae, Ani Shahbazian, Jennifer Wang, Daniela Markovic, Tiffany De Leon, Yuna Lee, Srinivasa T Reddy, Christina Charles-Schoeman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sangmee Sharon BaeUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA. sbae@mednet.ucla.edu.
Ani ShahbazianUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Jennifer WangUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Daniela MarkovicUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Tiffany De LeonUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Yuna LeeUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Srinivasa T ReddyUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.
Christina Charles-SchoemanUCLA David Geffen School of Medicine, Departmen of Medicine, Division of Rheumatology, University of California, 1000 Veteran Ave, Rm 32-59, Los Angeles, CA, 90095, USA.

Funding

Altered High-Density Lipoprotein function in Patients with Idiopathic Inflammatory MyopathiesK23AR081423 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sangmee Bae · 2023 to 2026
$728k
NIAMS NIH HHS K23 AR081423
6 · The paper itself

Abstract

objectiveTo evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (DM-ILD).

methodsWe performed a cross-sectional study in plasma samples from DM patients and matched healthy controls. Plasma ICAM-1 and VCAM-1 (CAM) levels were measured by ELISA. The activity of paraoxonase-1 (PON1), a high density lipoprotein (HDL) associated antioxidative enzyme was measured using paraoxonase, arylesterase and lactonase assays. Association analysis was performed between clinical predictors and CAM levels. We analyzed whether CAM levels have a mediating role in the association between PON1 activity and IIM outcomes using causal mediation analysis.

resultsPlasma samples from 83 DM patients with anti-Jo1 (n = 24), MDA5 (n = 29), and TIF1gamma (n = 30) and 28 age and sex matched healthy controls were analyzed. Plasma CAM levels were significantly higher in DM patients compared to controls. CAM levels were particularly higher in anti-MDA5 + DM patients compared to other autoantibody groups and in DM-ILD compared to DM without ILD. Higher ICAM-1 levels correlated low PON1 lactonase activity as well as worse restrictive lung physiology in multivariate models. Mediation analysis showed that 54% of the effect of low lactonase on worse DLCO was mediated through ICAM-1.

conclusionPlasma CAM levels were higher in DM patients compared to healthy controls, particularly in DM patients with ILD. Our analyses support a pathway of low PON1 lactonase activity representing poor HDL function with low protective capacity of microvessels allowing increased endothelial activation leading to DM and DM-ILD.

Indexed as

AryldialkylphosphataseDermatomyositisIntercellular Adhesion Molecule-1Lung Diseases, InterstitialVascular Cell Adhesion Molecule-1AdultAgedBiomarkersCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedAryldialkylphosphataseBiomarkersICAM1 protein, humanIntercellular Adhesion Molecule-1PON1 protein, humanVascular Cell Adhesion Molecule-1DermatomyositisIdiopathic inflammatory myopathyPolymyositis

Identifiers

PMID40055821
PMCPMC11889823

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.