Evidence map›Paper›PMID 40056301›Full record

ArticleDigestive diseases and sciences2025

Decreased Life Expectancy in Patients with Acute and Chronic Pancreatitis.

Satish Munigala, Divya S Subramaniam, Dipti P Subramaniam, Hong Xian, Sarah M Munigala, Krishna C Kottapalli, Thomas E Burroughs, Sunil G Sheth

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Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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4citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Satish MunigalaCollege for Public Health and Social Justice, Saint Louis University, HCOR Office St. Louis, 3545 Lafayette Ave, Salus Center 4th Floor, Saint Louis, MO, 63104, USA. satish.munigala@slu.edu.
Divya S SubramaniamDepartment of Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.
Dipti P SubramaniamDepartment of Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.
Hong XianDepartment of Epidemiology and Biostatistics, College for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA.
Sarah M MunigalaDepartment of Internal Medicine, Washington University in St. Louis, Saint Louis, MO, USA.
Krishna C KottapalliAscension St. Francis Hospital, Milwaukee, WI, USA.
Thomas E BurroughsCollege for Public Health and Social Justice, Saint Louis University, Saint Louis, MO, USA.
Sunil G ShethBeth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPopulation-based data on the life expectancy and mortality for acute (AP) and chronic pancreatitis (CP) in the United States are limited. This study evaluates the life expectancy, mortality rates and the cause of death in AP and CP patients.

methodsUsing the nationwide Veterans Administration database from 1999 to 2015, we identified AP and CP patients (using ICD-9 codes) and non-pancreatitis patients (controls). Age at the time of death was used as a surrogate indicator of life expectancy. Life expectancy in AP and CP patients was compared with the controls, using Cox-proportional hazards model. The mortality rates and cause of death for AP, CP, and controls were also assessed.

resultsOverall, we selected 35,550 AP and 12,545 CP patients and 100,000 controls. The life expectancy was significantly lower for both AP (69 years) and CP (71 years) patients compared to the controls (81 years, p < 0.001). The risk of mortality was higher for AP (adjusted hazard ratio (aHR) 1.61, 95% CI 1.58-1.65, p < 0.001) and CP (aHR 1.64, 95% CI 1.59-1.68, p < 0.001) than in controls. Approximately forty-two percent of all patients died during the follow-up (AP-44.3%, CP-52.1% and controls-39.7%). Circulatory disorders, neoplasms, and respiratory disorders were the leading causes of death in AP and CP patients.

conclusionsAcute and chronic pancreatitis are associated with decreased life span and higher mortality emphasizing their clinical importance. Although the deaths due to gastrointestinal/digestive system disorders were significantly higher, most of the deaths in AP and CP patients were primarily due to non-gastrointestinal causes.

Indexed as

Life ExpectancyPancreatitisPancreatitis, ChronicAcute DiseaseAdultAgedAged, 80 and overCause of DeathDatabases, FactualFemaleHumansMaleMiddle AgedUnited StatesAcute pancreatitisCause of deathInflammationLife expectancyMortality

Identifiers

PMID40056301

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.