Evidence map›Paper›PMID 40057742›Full record

ArticleEvoDevo2025

Shedding light on the embryogenesis and eye development of the troglophile cave spider Tegenaria pagana C. L. Koch, 1840 (Araneae: Agelenidae).

Evgenia A Propistsova, Guilherme Gainett, Ariel D Chipman, Prashant P Sharma, Efrat Gavish-Regev

Abstract read
In one paragraph

Article in EvoDevo, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Evgenia A PropistsovaThe Department of Ecology, Evolution and Behavior, The Hebrew University of Jerusalem, Jerusalem, Israel. evgeniia.propistsova@mail.huji.ac.il.
Guilherme GainettDepartment of Systems Biology, Harvard Medical School, Boston, USA.
Ariel D ChipmanThe Department of Ecology, Evolution and Behavior, The Hebrew University of Jerusalem, Jerusalem, Israel.
Prashant P SharmaDepartment of Integrative Biology, University of Wisconsin-Madison, Madison, USA.
Efrat Gavish-RegevThe National Natural History Collections, The Hebrew University of Jerusalem, Jerusalem, Israel.

Funding

Israel Science Foundation 570/21National Science Foundation IOS-2016141United States - Israel Binational Science Foundation 2019823United States - Israel Binational Science Foundation 3083000024
6 · The paper itself

Abstract

backgroundRelatively little is known about the diversity of embryonic development across lineages of spiders, even though the study of embryonic development is a primary step in evo-devo studies and essential for understanding phenotypic evolution. Practically nothing is known about embryogenesis in cave-dwelling spiders, animals which play an important role in cave ecosystems and may have remarkable adaptations to aphotic habitats such as loss of eyes.

resultsHere, we describe embryogenesis and study the expression patterns of several genes of the Retinal Determination Network (RDN) in the troglophile (species that have pre-adaptations to life in caves, and can complete their life cycle in caves, as well as in epigean habitats) eye-bearing funnel-web spider species Tegenaria pagana C. L. Koch, 1840, using fluorescent staining and confocal microscopy. We discuss the characteristic features of T. pagana embryogenesis and key RDN genes. Although in many respects the embryonic development of different species of entelegyne spiders is similar, we found differences in the rate of development, and the details of the opisthosoma, respiratory system, and brain morphogenesis in comparison with established spider model species. Our data supports the hypothesis of a conserved role of sine oculis gene in the eye formation of arachnids.

conclusionsGiven the recent discovery of congeneric cave species with different degrees of eye reduction throughout Israel, these data sets provide a foundational point of comparison for studying eye reduction and eye loss events in the spider genus Tegenaria.

Indexed as

Cave faunaDevelopmentEyesFunnel-web Spiders

Identifiers

PMID40057742
PMCPMC11889846

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.