ArticleCardiovascular diabetology2025
Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011-2018.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Association between metabolic score for insulin resistance and risk of cardiometabolic multimorbidity: an analysis based on two national prospective cohorts.Nutrition & metabolism · 2026Article
- Normal-Weight Obesity and Hidden Cardiometabolic Risk in Young Adults: Implications Beyond BMI-Based Classification.Medical sciences (Basel, Switzerland) · 2026Article
- Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Health and Retirement Longitudinal Study (CHARLS).Cardiovascular diabetology · 2026Article
- Effects of adiposity, insulin resistance, and inflammation on cardiometabolic multimorbidity: insights from interaction analyses and metabolic phenotyping in the China health and retirement longitudinal study 2011-2018.Cardiovascular diabetology · 2026Article
- Joint association of atherogenic index of plasma (AIP) and body roundness index (BRI) with cardiometabolic multimorbidity in adults in Guangzhou, China.Cardiovascular diabetology · 2026Article
- Predictive value of the combined cholesterol, high-density lipoprotein, glucose and frailty indices for cardiometabolic multimorbidity incidence: evidence from a national prospective cohort study.Cardiovascular diabetology · 2026Article
- A body shape index trajectories and cognitive function among older hypertensive patients: a national cohort study.Archives of public health = Archives belges de sante publique · 2026Article
- Comparative effects of central adiposity and BMI trajectories on cardiometabolic diseases in Chinese adults: a longitudinal cohort study.Lipids in health and disease · 2026Article
- Associations between the C-reactive protein-triglyceride glucose index and the incidence and progression trajectory of cardiometabolic multimorbidity: a multi-state model study.Cardiovascular diabetology · 2026Article
- Assessment of seven insulin resistance surrogate indexes for predicting cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.Cardiovascular diabetology · 2026Article
- Association between hearing impairment and cardiometabolic multimorbidity among middle-aged and older adults in China.Scientific reports · 2026Article
- Effect of Small Dense Low-Density Lipoprotein Cholesterol Combined With High-Sensitivity C-Reactive Protein on Cardiometabolic Multimorbidity: A National Cohort Study.Clinical cardiology · 2026Observational
- Development and validation of a nomogram to predict the risk of cardiometabolic multimorbidity in older adults: data from the NHANES database.BMC cardiovascular disorders · 2026Article
- Review
- The combined effects of cardiometabolic index and high sensitivity C-reactive protein on cardiometabolic multimorbidity risk: a prospective analysis based on CHARLS.Lipids in health and disease · 2026Article
- The association of C-reactive protein-triglyceride-glucose index with cardiometabolic multimorbidity in middle-aged and older adults: evidence from two cohort studies.Cardiovascular diabetology · 2026Article
- Data-driven glycolipid network phenotypes reveal a graded risk spectrum for cardiometabolic multimorbidity: a prospective study in middle-aged and older Chinese adults.Lipids in health and disease · 2026Article
- Association of the triglyceride glucose-Chinese visceral adiposity index with incident cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
- Association and predictive performance of the ZJU index for incident cardiometabolic multimorbidity in middle-aged and older adults: a 10-year prospective cohort study.Journal of health, population, and nutrition · 2026Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundObesity and abnormal lipid metabolism increase the risk of various cardiometabolic diseases, including diabetes, heart disease, and stroke. However, the impact of abdominal obesity (AO) and non-traditional lipid parameters on the risk of cardiometabolic multimorbidity (CMM) remains unclear. This study aims to investigate the separate and combined effects of AO and non-traditional lipid parameters on the incidence risk of CMM.
methodsThis study enrolled 7,597 eligible participants from the China health and retirement longitudinal study (CHARLS). Cox proportional hazards models were used to perform adjusted regression analyses and mediation analyses, with Kaplan-Meier analysis used for cumulative hazards. Restricted cubic splines were utilized to evaluate the nonlinear relationship between non-traditional lipid parameters and the risk of CMM among participants with AO. Subgroup analyses were conducted with stratification by age, gender, BMI, smoking status, drinking status, and hypertension to investigate interaction effects across different populations. Additionally, sensitivity analyses were further performed to evaluate the impact of various subgroups on diabetes, heart disease, and stroke.
resultsDuring the 7-year follow-up period, a total of 699 participants (9.20%) were newly diagnosed with CMM. Kaplan-Meier curves revealed that the subgroup with both AO and high levels of non-traditional lipid parameters had the highest cumulative hazard for developing CMM. In the fully adjusted model, Cox regression analysis revealed that participants with both high levels of non-traditional lipid parameters and AO exhibited the highest risk of developing CMM. Subgroup and sensitivity analyses further confirmed the robustness of these findings, showing consistent results across different demographic groups and under various analytical conditions. Furthermore, AO was found to significantly mediated the associations between non-traditional lipid parameters and the risk of developing CMM.
conclusionThe separate and combined effects of AO and non-traditional lipid parameters were significantly associated with the risk of developing CMM. Notably, AO may induce CMM by partially mediating the effects of serum lipids in human metabolism. The findings highlighted the importance of joint evaluation of AO and non-traditional lipid parameters for primary prevention of CMM.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.