ArticleBrain and behavior2025
Early Predictive Value of the Glucose-to-Lymphocyte Ratio for the Occurrence of Stroke-Associated Pneumonia.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association of Admission Glucose-to-Lymphocyte Ratio With 90-Day Functional Outcome in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis.Brain and behavior · 2026Article
- Risk estimation for stroke-associated pneumonia in acute ischemic stroke: a nomogram-based approach.Arquivos de neuro-psiquiatria · 2026Article
- Evaluating the role of glucose-to-lymphocyte ratio as a prognostic indicator in pediatric moderate to severe traumatic brain injury.European journal of medical research · 2025Article
- Do diabetes and poor control of acute stress-related hyperglycemia increase the risk of ICU-acquired infections? A retrospective assessment in patients with septic shock.Annals of intensive care · 2025Article
- Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model.Frontiers in neurologyArticle
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9 authors.
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Abstract
BACKGROUND AND
objectiveHyperglycemia and poststroke immunosuppression can lead to a decline in immune function, resulting in an increased incidence of infectious events. The relationship between the glucose-to-lymphocyte ratio (GLR), a novel indicator, and stroke-associated pneumonia (SAP) remains unclear. The objective of this study is to investigate the early predictive value of the GLR in the context of SAP.
methodsA retrospective analysis was conducted on acute stroke patients admitted to the Department of Neurology at the First Affiliated Hospital of Kunming Medical University from 2017 to 2021. The dataset included demographic information, vascular risk factors, and laboratory test results. Logistic regression analysis was used to assess the correlation between the GLR and the incidence of SAP. The GLR was converted into a categorical variable for trend testing, and compared the predictive efficiency of GLR through the receiver operating characteristic (ROC) curve and Bonferroni correction analysis.
resultsThis study included 711 patients with acute stroke according to a 1:2 case-control ratio, with 237 (33.3%) in the SAP group and 474 (66.7%) in the Non-SAP group. The baseline level of the GLR was significantly greater in the SAP group than in the Non-SAP group (p < 0.001). After correction using multifactorial logistic regression analysis, GLR (OR: 1.182, 95% CI: 1.090-1.281, p < 0.001) was identified as an independent risk factor for SAP. When GLR was converted into a categorical variable, the risk of SAP in group Q3 was 3.210 times greater than that in group Q1, and the trend test yielded p < 0.001. The analysis of the ROC curve revealed that the area under the curve (AUC) for the GLR was 0.737, with a sensitivity of 70.0% and specificity of 67.1% at a cutoff value of 4.110. The predictive efficacy of the GLR for SAP patients was superior to that of either blood glucose or lymphocyte counts alone (p < 0.0167).
conclusionsAn elevated GLR within 24 h of hospital admission following an acute stroke is an independent risk factor for SAP. The risk of SAP increases progressively with increasing GLR, suggesting that the GLR may have a certain early predictive value for the occurrence of SAP.
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