Evidence map›Paper›PMID 40059488›Full record

ArticleCancer2025

Glioma mutational signatures associated with haloalkane exposure are enriched in firefighters.

Vincent L Cannataro, Paige M Bracci, Jennie W Taylor, Lucie McCoy, Terri Rice, Helen M Hansen, Anne E Heffernan, Joseph Wiemels, John Wiencke, Margaret Wrensch and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Environmental Hazards and Glial Brain Tumors: Association or Causation?International journal of molecular sciences · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vincent L CannataroDepartment of Biology, Emmanuel College, Boston, Massachusetts, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Jennie W TaylorDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Lucie McCoyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Terri RiceDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Helen M HansenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Anne E HeffernanDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0009-9043-3750
Joseph WiemelsDepartment of Population and Public Health Sciences, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
John WienckeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Margaret WrenschDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA.
Elizabeth B ClausDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9867-8124

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Participant Engagement UnitU2CCA252979 · NCI · YALE UNIVERSITY · PI Bethany Matthews Kwan, Roel GW Verhaak · 2021 to 2026
$15.5M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rashmi Joglekar · 2020 to 2026
$11.2M
Training in Molecular& Genetic Epidemiology of CancerR25CA112355 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WITTE, JOHN S. · 2005 to 2018
$6.5M
Biomarkers of survival in glioma epidemiologyR01CA126831 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2008 to 2013
$2.5M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
NCCDPHP CDC HHS NU58DP006344NCI NIH HHS HHSN261201800009CNCI NIH HHS HHSN261201800009INCI NIH HHS HHSN261201800015CNCI NIH HHS HHSN261201800015INCI NIH HHS HHSN261201800032CNCI NIH HHS HHSN261201800032INCI NIH HHS P30 CA082103NCI NIH HHS P50 CA097257NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA126831NCI NIH HHS R01 CA139020NCI NIH HHS R25 CA112355NCI NIH HHS U2C CA252979NCRR NIH HHS UL1 RR024131NIEHS NIH HHS P30 ES030284NIH HHS 5U2C-CA252979NIH HHS P50CA097257NIH HHS R01CA52689NIH HHS S10 OD030363
6 · The paper itself

Abstract

backgroundGlioma is the most common malignant primary brain tumor and is associated with significant morbidity and mortality. Modifiable risk factors remain unidentified. New advances in exposure assessment, genomic analyses, and statistical techniques permit more accurate evaluation of glioma risk associated with exogenous occupational or environmental exposures.

methodsBy using whole-exome sequencing data from matched germline and glioma tumor samples, the authors compared tumor mutational signatures for 17 persons with glioma and a documented occupational history of firefighting with those of 18 persons with glioma without an occupational history of firefighting. All 35 individuals were participants in the University of California, San Francisco Adult Glioma Study.

resultsThere was a positive correlation among firefighters between the median number of sample variants attributable to single-base substitution signature 42, a single-base substitution mutational signature associated with haloalkane exposure (from the Catalogue of Somatic Mutational Signatures in Cancer) and firefighting years (p = .04; R

conclusionsIn summary, the authors identified gliomas that had mutational signatures associated with haloalkane exposure that were enriched in firefighters and other occupations.

Indexed as

Brain NeoplasmsFirefightersGliomaMutationOccupational ExposureAdultAgedExome SequencingFemaleHumansMaleMiddle Agedepidemiologyfirefightersgliomahaloalkanemutationoccupationsignature

Identifiers

PMID40059488
PMCPMC11891468

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.