Evidence map›Paper›PMID 40059537›Full record

ReviewWiley interdisciplinary reviews. RNA

Post-Transcriptional Regulation of Gene Expression and the Intricate Life of Eukaryotic mRNAs.

Carly L Lancaster, Kenneth H Moberg, Anita H Corbett

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. RNA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Role of mEpigenomes · 2025
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carly L LancasterDepartment of Biology, Emory College of Arts and Sciences, Atlanta, Georgia, USA.
Kenneth H MobergDepartment of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, USA.
Anita H CorbettDepartment of Biology, Emory College of Arts and Sciences, Atlanta, Georgia, USA.ORCID 0000-0002-0461-6895

Funding

Training Program in Biochemistry, Cell and Molecular BiologyT32GM135060 · NIGMS · EMORY UNIVERSITY · PI Lawrence H. Boise, ANITA H. CORBETT · 2020 to 2026
$2.8M
A Conserved RNA Binding Protein Required for Control of Key Developmental PathwaysR01NS125768 · NINDS · EMORY UNIVERSITY · PI ANITA H. CORBETT, Kenneth H Moberg · 2022 to 2026
$1.9M
Control of Drosophila intestinal homeostasis by RhoGap15bR56AG085250 · NIA · EMORY UNIVERSITY · PI MOBERG, KENNETH H · 2024 to 2024
$381k
A Conserved RNA Binding Protein Regulates RNAs Critical for NeurodevelopmentF31NS127545 · NINDS · EMORY UNIVERSITY · PI LANCASTER, CARLY L · 2022 to 2024
$143k
NIA NIH HHS R56 AG085250NIGMS NIH HHS T32 GM135060NINDS NIH HHS F31 NS127545NINDS NIH HHS R01 NS125768
6 · The paper itself

Abstract

In recent years, there has been a growing appreciation for how regulatory events that occur either co- or post-transcriptionally contribute to the control of gene expression. Messenger RNAs (mRNAs) are extensively regulated throughout their metabolism in a precise spatiotemporal manner that requires sophisticated molecular mechanisms for cell-type-specific gene expression, which dictates cell function. Moreover, dysfunction at any of these steps can result in a variety of human diseases, including cancers, muscular atrophies, and neurological diseases. This review summarizes the steps of the central dogma of molecular biology, focusing on the post-transcriptional regulation of gene expression.

Indexed as

Gene Expression RegulationRNA, MessengerRNA Processing, Post-TranscriptionalAnimalsHumansRNA, Messengercentral dogmagene expressionmessenger RNARNA binding proteintranslation

Identifiers

PMID40059537
PMCPMC11949413

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.