Evidence map›Paper›PMID 40059776›Full record

ArticleHistology and histopathology2025

Pinocembrin ameliorates non-alcoholic fatty liver disease by activating Nrf2/HO-1 and inhibiting the NF-κB signaling pathway.

Weina Chen, Diming Xue, Xia Feng, Yinhang Zhong, Quanqing Li, Weihang Zhang, Guojun Jiang

Abstract read
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Article in Histology and histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weina Chen *Department of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Diming Xue *Department of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Xia FengDepartment of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Yinhang ZhongDepartment of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Quanqing LiDepartment of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Weihang Zhang *Department of Traditional Chinese Medicine, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Guojun Jiang *Department of Pharmacy, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China. jguojun999@hznu.edu.cn.

Funding

Project of Guiding Major Science and Technology Programme for Social Development of Science and Technology Bureau of Xiaoshan District, Hangzhou 2022331
6 · The paper itself

Abstract

objectivesThe high intake of high-fat diets and changes in sedentary lifestyles have led to an increase in non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the effect and mechanism of Pinocembrin (Pin) on NAFLD

methodsThe pharmacodynamics of Pin alone or in combination with ML385 was assessed in high-fat diet (HFD)-mediated NAFLD mice. HepG2 cells were treated with palmitic acid (PA)/oleic acid (OA) (1:2) as an

resultsPin alleviated lipid deposition, inflammatory response, and oxidative stress in HFD-induced NAFLD mice and PA/OA-induced HepG2 cells. Moreover, ML385 partly attenuated the protection of Pin on inflammatory response and oxidative stress

conclusionTaken together, these results indicated that Pin alleviated glucose and lipid metabolism disorders, inflammation, and oxidative stress in NAFLD by activating the Nrf2/HO-1 signaling pathway and restraining the NF-κB pathway.

Indexed as

FlavanonesHeme Oxygenase-1NF-E2-Related Factor 2NF-kappa BNon-alcoholic Fatty Liver DiseaseSignal TransductionAnimalsDiet, High-FatDisease Models, AnimalHep G2 CellsHumansLipid MetabolismLiverMaleMembrane ProteinsMiceFlavanonesHeme Oxygenase-1Hmox1 protein, mouseMembrane ProteinsNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa Bpinocembrin

Identifiers

PMID40059776

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.