Evidence map›Paper›PMID 40059816›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis.

Rakesh Radhakrishnan, Matthias Leung, Anjelynt Lor, Swati More, Glenn P Lobo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  4. Loss of the vitamin A receptor RBPR2 in mice disrupts whole-body retinoid homeostasis and the quantitative balance regulating retinylidene protein synthesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Rakesh RadhakrishnanDepartment of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-3865-0220
Matthias LeungDepartment of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8378-8272
Anjelynt LorDepartment of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0009-0004-9658-756X
Swati MoreCenter for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0002-8733-2029
Glenn P LoboDepartment of Ophthalmology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-2698-1989

Funding

Physiological Role of the Vitamin A Transporter RBPR2 for VisionR01EY030889 · NEI · UNIVERSITY OF MINNESOTA · PI LOBO, GLENN P · 2020 to 2024
$1.8M
HHS | NIH | National Eye Institute (NEI) 3R01EY030889-03S1HHS | NIH | National Eye Institute (NEI) EY030889NEI NIH HHS R01 EY030889
6 · The paper itself

Abstract

The distribution of stored dietary vitamin A/all-trans-retinol (ROL) from the liver throughout the body is critical for maintaining retinoid function in peripheral tissues and for generating visual pigments for photoreceptor cell function. ROL circulates in the blood bound to the retinol binding protein 4 (RBP4) as RBP4-ROL. Two membrane receptors, RBPR2 in the liver and other non-ocular tissues, and STRA6 in the eye are proposed to bind circulatory RBP4 and this mechanism facilitates the internalization of ROL. Herein, we conducted a longitudinal study to investigate the importance of RBPR2 and influence of vitamin A content in the diet on whole-body retinoid homeostasis and its effects on chromophore production in the support of visual function. Rbpr2-knockout (Rbpr2

Indexed as

HomeostasisRetinoidsAnimalsLiverMaleMiceMice, Inbred C57BLMice, KnockoutRetinol-Binding Proteins, PlasmaVitamin AVitamin A DeficiencyRbp4 protein, mouseRetinoidsRetinol-Binding Proteins, PlasmaVitamin Aall‐trans‐retinolphotoreceptorsretinoidsretinol‐binding protein 4retinol‐binding protein 4 receptor 2rhodopsinstimulated by retinoic acid 6vitamin A

Identifiers

PMID40059816
PMCPMC11891820

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.