Evidence map›Paper›PMID 40059963›Full record

ArticleToxicology reports2025

Safety assessment of resveratrol surrogate molecule 5 (RSM5): Acute and sub-acute oral toxicity studies in BALB/c mice.

Arunkumar Subramanian, T Tamilanban, Amar Daud Iskandar Abdullah, V Chitra, Mahendran Sekar, Gomathi Swaminathan, Inderjeet Yadav, V Manimaran, Vinibha Rajakumari, Vetriselvan Subramaniyan

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In one paragraph

Article in Toxicology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arunkumar SubramanianDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu 603203, India.
T TamilanbanDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu 603203, India.
Amar Daud Iskandar AbdullahDepartment of Biological Sciences, School of Medical and Life Sciences, Sunway University Jalan University, Bandar Sunway, Darul Ehsan, Selangor 47500, Malaysia.
V ChitraDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu 603203, India.
Mahendran SekarSchool of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya, Selangor 47500, Malaysia.
Gomathi SwaminathanDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research, The Nilgiris, Ooty, Tamil Nadu 643001, India.
Inderjeet YadavNational Brain Research Centre, Manesar, Haryana, India.
V ManimaranDepartment of Pharmaceutical Quality Assurance, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu 603203, India.
Vinibha RajakumariCentre for Pre-University Studies, MAHSA University Malaysia, Malaysia.
Vetriselvan SubramaniyanDepartment of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu, Tamil Nadu 603203, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural polyphenols have gained greater attention for their potent medicinal properties and potential benefits in addressing various health concerns. Resveratrol, a polyphenolic compound known for its therapeutic properties, has shown limitations in bioavailability, which the novel derivative resveratrol surrogate molecule (RSM5) aims to improve. The present study evaluates the oral toxicity and safety profile of a novel resveratrol derivative through acute and subacute assessments. Acute toxicity was assessed following a single oral administration, while subacute toxicity was evaluated after repeated doses over 28 days in BALB/c mice. Various physiological, biochemical, and histopathological parameters were monitored to determine potential adverse effects. The findings indicate that the RSM5 exhibits no significant toxic effects at the tested doses (15, 30, 60 mg/kg), with both acute and subacute studies showing a favourable safety profile. These results suggest that the novel resveratrol derivative may be safe for further pharmacological development, supporting its potential for therapeutic applications.

Indexed as

Acute and Sub-acuteResveratrol surrogate moleculeSafety AssessmentSchiff baseToxicity study

Identifiers

PMID40059963
PMCPMC11889660

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.