Evidence map›Paper›PMID 40060172›Full record

ArticleAmerican journal of preventive cardiology2025

Under-recognized cardiovascular risk enhancers in women: A call to rethink clinical assessment on risk stratification.

Albertina M Ghelfi, Gustavo J Staffieri, Mildren A Del-Sueldo, Gonzalo Miranda, Nicolás F Renna, Rosana M Quintana, Melisa N Lassus, María-Rosa Galván, Romina Maldonado, Flavia A Passarino and 9 more

Abstract read
In one paragraph

Article in American journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Albertina M GhelfiUnidad de Hipertensión Arterial y Riesgo Cardiovascular, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
Gustavo J StaffieriSociedad Argentina de Hipertensión Arterial. Ciudad Autónoma de Buenos Aires, Argentina.
Mildren A Del-SueldoSociedad Argentina de Hipertensión Arterial. Ciudad Autónoma de Buenos Aires, Argentina.
Gonzalo MirandaSociedad Argentina de Hipertensión Arterial. Ciudad Autónoma de Buenos Aires, Argentina.
Nicolás F RennaSociedad Argentina de Hipertensión Arterial. Ciudad Autónoma de Buenos Aires, Argentina.
Rosana M QuintanaUniversidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud Sede Rosario. Rosario, Santa Fe, Argentina.
Melisa N LassusUnidad de Hipertensión Arterial y Riesgo Cardiovascular, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
María-Rosa GalvánServicio de Retrovirus, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
Romina MaldonadoUnidad de Hipertensión Arterial y Riesgo Cardiovascular, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
Flavia A PassarinoUniversidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud Sede Rosario. Rosario, Santa Fe, Argentina.
Lautaro N FierroServicio de Tocoginecología, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
Lautaro L VelezUniversidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud Sede Rosario. Rosario, Santa Fe, Argentina.
Laura GrazianiHospital Español de Mendoza. Godoy Cruz, Mendoza, Argentina.
Boris KislukUnidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, Argentina.
Leonel A BerbottoUniversidad Abierta Interamericana. Centro de Altos Estudios en Ciencias Humanas y de la Salud Sede Rosario. Rosario, Santa Fe, Argentina.
Romina NietoUnidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, Argentina.
Rubén F Mamprin D AndreaUnidad de Hipertensión Arterial y Riesgo Cardiovascular, Hospital Escuela Eva Perón. Granadero Baigorria, Santa Fe, Argentina.
Guillermo A BerbottoUnidad de Enfermedades Autoinmunes, Hospital Escuela Eva Perón, Argentina.
Jorge O GalindezServicio de Clínica Médica, Hospital Escuela Eva Perón, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Traditional cardiovascular risk (CVR) stratification does not consider CVR enhancers (CVRE). Women present under-recognized CVRE factors that may lead to arterial stiffness (AS). AS is associated with long-term cardiovascular disease. AS can be determined by carotid-femoral pulse wave velocity (cf-PWV). In women with low-CVR and a CVRE, our objective was to determine cf-PWV values and AS, and to compare with a control group. Material and Methods: Multicentric cross-sectional study, from 2022 to 2024 in Argentina. Included women between 18 and 59 years-old, without traditional CVR-factors, low (<5 %) 10-year CVR, and office blood-pressure (BP) <140/90 mmHg. Inclusion criteria: Group 1: presence of a CVRE (history of gestational hypertension, preeclampsia; autoimmune rheumatic or hematological disease in clinical remission; previous oncological treatment in current complete remission; history of abortions; early menopause or menarche; anxiety or depression disorder; human immunodeficiency virus infected virally suppressed). Group-2: women who attended routine control. Exclusion criteria: hypertension; diabetes; target organ damage; chronic kidney disease; current smoking; history of CV-event; statins, aspirin, or antihypertensive treatment. Results: Included 280 women: Group-1 (N = 174); Group-2 (N = 106). Group-1 showed higher cf-PWV: 7.02±1.20 vs. 5.71±0.86 ( Conclusions: Women with CVRE showed greater cf-PWV and higher frequency of AS.

Indexed as

Arterial stiffnessCardiovascular diseaseCardiovascular risk factorsHypertensionPulse wave velocityWomen´s health

Identifiers

PMID40060172
PMCPMC11889624

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.