Evidence map›Paper›PMID 40060598›Full record

ArticlebioRxiv : the preprint server for biology2025

Multi-omic analysis of the ciliogenic transcription factor

Jenny Lai, Didem Demirbas, Kaitlyn Phillips, Boxun Zhao, Harrison Wallace, Megan Seferian, Tojo Nakayama, Holly Harris, Aikaterini Chatzipli, Eunjung Alice Lee and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jenny LaiDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0002-4720-9229
Didem DemirbasDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Kaitlyn PhillipsDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Boxun ZhaoDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0003-2337-5756
Harrison WallaceDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Megan SeferianDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Tojo NakayamaDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Holly HarrisDepartment of Pediatrics, Baylor College of Medicine and Meyer Center for Developmental Pediatrics, Texas Children's Hospital, Houston, Texas, 77054, USA.
Aikaterini ChatzipliDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Eunjung Alice LeeDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.
Timothy W YuDivision of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA, 02115, USA.ORCID 0000-0003-2988-7701

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Complete gene knockouts in autism: identification and functional characterizationR01MH113761 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI YU, TIMOTHY WEI-WEN · 2017 to 2021
$2.2M
The molecular roles of RFX3 in neurodevelopment and Autism Spectrum disorderF30MH128995 · NIMH · HARVARD MEDICAL SCHOOL · PI LAI, JENNY · 2022 to 2023
$92k
NICHD NIH HHS P50 HD105351NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIMH NIH HHS F30 MH128995NIMH NIH HHS R01 MH113761
6 · The paper itself

Abstract

Heterozygous loss-of-function (LoF) variants in

Indexed as

activity-dependenceautismCUT&RUN-seqhuman iPSCneurodevelopmentorganoidsRFXscRNA-seqsynaptic plasticitytranscriptomics

Identifiers

PMID40060598
PMCPMC11888390

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.