Evidence map›Paper›PMID 40060667›Full record

ArticlebioRxiv : the preprint server for biology2025

Radiation damage to a three-dimensional hydrogel model of the brain perivascular niche.

Y I Ivanova, A C Nunes, V Cruz, K Selting, B A C Harley

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Y I IvanovaDept. of Bioengineering, University of Illinois at Urbana-Champaign Urbana, IL 61801.
A C NunesCarl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign Urbana, IL 61801.
V CruzDept. of Materials Science and Engineering, University of Illinois at Urbana-Champaign Urbana, IL 61801.
K SeltingCancer Center at Illinois, University of Illinois at Urbana-Champaign Urbana, IL 61801.
B A C HarleyCancer Center at Illinois, University of Illinois at Urbana-Champaign Urbana, IL 61801.ORCID 0000-0001-5458-154X

Funding

Synthetic manipulation of engineered perivascular nichesR01CA256481 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI HARLEY, BRENDAN A. · 2021 to 2025
$3.4M
NCI NIH HHS R01 CA256481
6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly aggressive and recurrent brain cancer characterized by diffuse metastasis at the tumor margins. Radiation therapy is a standard component of current treatment and offers potential for improved patient outcomes. While radiation therapy targets GBM cells in the tumor margins, it may also significantly damage adjacent non-cancerous tissues, leading to reduced quality of life and potentially creating a tumor-supportive microenvironment. The perivascular niche (PVN) in the tumor margins is believed to play a significant role in regulating the glioblastoma stem cell subpopulation as well as serving as a site for cancer recurrence and migration. Understanding the impact of radiation on the PVN can better inform radiation schemes and improve our understanding of GBM recurrence, but is difficult

Indexed as

brainglioblastomahydrogelperivascular nicheradiation

Identifiers

PMID40060667
PMCPMC11888163

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.