Evidence map›Paper›PMID 40060812›Full record

ArticleACS omega2025

Acute Toxicity and Antihyperlipidemic Effects of Syringaldehyde with Downregulation of SREBP-2 Gene Expression in Rats.

Misbah Imtiaz, Nabi Shah, Muhammad Ikram, Zia Uddin, Qurat-Ul-Ain, Abdulhakeem S Alamri, Majid Alhomrani, Abdul Jabbar Shah

Abstract read
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In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Misbah ImtiazPharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Nabi ShahPharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.ORCID https://orcid.org/0000-0003-2764-3615
Muhammad IkramImmune Cell Molecular Pharmacology Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Zia UddinPharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.
Qurat-Ul-AinRiphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, 54000 Lahore, Pakistan.
Abdulhakeem S AlamriDepartment of Clinical Laboratory Sciences, the Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Majid AlhomraniDepartment of Clinical Laboratory Sciences, the Faculty of Applied Medical Sciences, Taif University, Taif 21944, Saudi Arabia.
Abdul Jabbar ShahPharmacogenetics Research Lab, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Abbottabad 22060, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperlipidemia, a condition characterized by elevated lipid levels, presents significant cardiovascular risks. Syringaldehyde (SA), a phenolic aldehyde derived from plants, exhibits antioxidant, antihyperglycemic, and anti-inflammatory properties. However, its potential toxicity and effects on hyperlipidemia have not been studied. In this study, we evaluated the safety profile and antihyperlipidemic effects of SA. To assess acute toxicity, Sprague-Dawley rats were divided into two groups (

Identifiers

PMID40060812
PMCPMC11886728

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.