ReviewACS omega2025
Anticancer Activities of Natural and Synthetic Steroids: A Review.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cholest-5-ene- and Stigmasta-5,22-diene-Based 1,3-Oxathiolan-5-one Lactones and an Aminothiazole-Diosgenin Hybrid: Synthesis and Preliminary Antimicrobial Activity.Molecules (Basel, Switzerland) · 2026Article
- Investigation on the Cytotoxicity of Hydroxycinnamic and Hydroxybenzoic Acid-Based Natural Antioxidant Conjugated Terpyridine Analogues toward Triple-Negative Breast Cancer.ACS medicinal chemistry letters · 2026Article
- Antitumor-Directed Fractionation ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Synthesis and antitumor activity of steroid-based imidazolium salts.RSC advances · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Steroids have demonstrated a wide field of research on the subject of anticancer compounds, particularly antiproliferative with cell lines, with special emphasis on the historical link between steroids and cancer and the use of in silico technologies to understand the impact of natural and synthetic steroids on cancer cells focused on finding common denominators of the type of structural changes that give antiproliferative and/or cytotoxic properties, both in control and cancer cell lines. Through this review and classification by origin and/or synthesis, it is found that steroidal saponins are highly cytotoxic, although with low selectivity against control cells, while on the part of the aglycone the presence of heteroatoms such as nitrogen and oxygen increases the antiproliferative activity, mainly via cell cycle arrest and the induction of apoptosis, mechanisms that have been partially proven, using semisynthetic derivatives, as well as bioconjugates between saponins and nitrogenous steroids with now a high cytotoxicity and selectivity against control cell lines. This gives rise to the idea that steroids as a study model for the design of anticancer agents are an excellent template with a wide field of study.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.