ArticleJBMR plus2025
Frailty and osteoporotic fractures represent mutual risks for each other with common physiological backgrounds.
Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations Between Peripheral Blood Inflammatory and Immune Markers and Osteoporotic and Fragility Fractures: A Systematic Review and Meta-Analysis.Calcified tissue international · 2026Pooled it
- Validation and refinement of a biomarker panel for frailty assessment and prediction of muscle weakness in older adults.npj aging · 2026Article
- Predictive value of the 5-factor modified frailty index for pneumonia in older adults with cervical spinal cord injury.Spinal cord · 2026Article
- Association of frailty trajectories with osteoporosis and hip fracture in an older female population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study.Frontiers in nutrition · 2026Article
- Differential Effects of Vitamin C from Fruit and Vegetables Versus Supplements on the Risk of Frailty.Nutrients · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty and osteoporosis are known to exacerbate each other. However, limited research is available on the shared pathophysiological factors contributing to osteoporotic fractures and frailty. This study aims to identify common factors associated with both the current frailty and the occurrence of incident vertebral fractures. A total of 912 postmenopausal Japanese women, 63.9 ± 10.0 yr of age (mean ± SD), were included in this study. Each participant's baseline frailty status was assessed using a questionnaire about the following 5 items: fatigue, resistance, ambulation, inactivity, and weight loss. A score of 3 or above indicated the prevalence of frailty. The participants were then followed up for an average of 10.5 ± 7.5 yr, during which 202 patients suffered incident vertebral fractures. The Cox proportional hazards model for incident vertebral fracture revealed that lumbar bone mineral density (hazard ratio [HR] 0.753,
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Registered trials
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